FMS-like tyrosine kinase 3/FLT3: from basic science to clinical implications
JU Kazi, L Rönnstrand - Physiological reviews, 2019 - journals.physiology.org
FMS-like tyrosine kinase 3 (FLT3) is a receptor tyrosine kinase that is expressed almost
exclusively in the hematopoietic compartment. Its ligand, FLT3 ligand (FL), induces …
exclusively in the hematopoietic compartment. Its ligand, FLT3 ligand (FL), induces …
ETV6 gene aberrations in non-haematological malignancies: A review highlighting ETV6 associated fusion genes in solid tumors
Abstract ETV6 (translocation-Ets-leukemia virus) gene is a transcriptional repressor mainly
involved in haematopoiesis and maintenance of vascular networks and has developed to be …
involved in haematopoiesis and maintenance of vascular networks and has developed to be …
Native and tagged CENP-A histones are functionally inequivalent
M Bui, S Baek, RS Bentahar, DP Melters… - Epigenetics & Chromatin, 2024 - Springer
Background Over the past several decades, the use of biochemical and fluorescent tags has
elucidated mechanistic and cytological processes that would otherwise be impossible. The …
elucidated mechanistic and cytological processes that would otherwise be impossible. The …
Driving the degradation of oncofusion proteins for targeted cancer therapy
X Zhang, Y Chen, B Yang, X Shao, M Ying - Drug Discovery Today, 2023 - Elsevier
Highlights•Oncofusion proteins drive the development of numerous cancers.•Oncofusion
proteins present extremely high stability by escaping degradation.•Triggering the …
proteins present extremely high stability by escaping degradation.•Triggering the …
Small molecule induced FLT3 degradation
SY Han - Pharmaceuticals, 2022 - mdpi.com
Target protein degrader is a new paradigm in the small molecule drug discovery field and
relates to the term 'event-driven pharmacology'. Fms-like tyrosine kinase 3 (FLT3) is a …
relates to the term 'event-driven pharmacology'. Fms-like tyrosine kinase 3 (FLT3) is a …
[HTML][HTML] Sorafenib Induced Complete Cytogenetic and Molecular Response in a Chronic Eosinophilic Leukemia Case with t (12; 13) Translocation
F Ricci, S Balducci, F Guerrini, S Grassi… - Clinical Hematology …, 2020 - ncbi.nlm.nih.gov
Hypereosinophilia (HE) is defined as a persistent increase in absolute eosinophil counts
(AEC) to levels> 1.5× 109/L. HE can be 'primary'or 'secondary', more often accompanying …
(AEC) to levels> 1.5× 109/L. HE can be 'primary'or 'secondary', more often accompanying …
[PDF][PDF] Nghiên cứu xác định ảnh hưởng của (-) epigallocatechin (egc) trên các dòng tế bào mang tổ hợp gen ETV6-NTRK3= A study for determining the effect of (-) …
TKL Bùi, TYN Trần - 2022 - thuvienlamdong.org.vn
Epigallocatechin (EGC) là một trong những hợp chất trong nhóm catechin đóng vai trò quan
trọng trong việc tạo nên hoạt tính sinh học của trà. Tuy đã có nhiều nghiên cứu trước đây …
trọng trong việc tạo nên hoạt tính sinh học của trà. Tuy đã có nhiều nghiên cứu trước đây …