Transient receptor potential (TRP) channels are one primary type of calcium (Ca 2+)
permeable channels, and those relevant transmembrane and intracellular TRP channels …

Biophysical cues from the cellular microenvironment are detected by mechanosensitive
machineries that translate physical signals into biochemical signaling cascades. At the …

Crosstalk between ion channels and small GTPases is critical during homeostasis and
disease, but little is known about the structural underpinnings of these interactions. TRPV4 is …

Hepatocellular carcinoma (HCC) is a malignant tumor, frequently causing both intrahepatic
and extrahepatic metastases. The overall prognosis of patients with metastatic HCC is poor …

Ion channels play a crucial role in a wide range of biological processes, including cell cycle
regulation and cancer progression. In particular, the transient receptor potential (TRP) family …

Lung cancer remains a major public health concern among all cancer diseases due to the
toxicity and side-effects of the available commercially synthesized drugs. Natural product …

Cytosolic Ca2+ signals are organized in complex spatial and temporal patterns that underlie
their unique ability to regulate multiple cellular functions. Changes in intracellular Ca2+ …

The search for new therapeutical targets for cutaneous melanoma and other cancers is an
ongoing task. We expanded this knowledge by evaluating whether opsins, light-and thermo …

Transient receptor potential melastatin 4 (TRPM4) is widely expressed in various organs
and associated with cardiovascular and immune diseases. Lately, the interest in studies on …

Background: Doxorubicin is a widely used and effective chemotherapy, but the major limiting
side effect is cardiomyopathy which in some patients leads to congestive heart failure …