Abstract The Immunoglobulin G (IgG) glycome is well known for its heterogeneity and shows
a significant degree of variation within populations. IgG glycome composition is influenced …

Inflammaging is a recent theory of aging originally proposed in 2000 where data and
conceptualizations regarding the aging of the immune system (immunosenescence) and the …

The severity and outcome of coronavirus disease 2019 (COVID-19) largely depends on a
patient's age. Adults over 65 years of age represent 80% of hospitalizations and have a 23 …

Protein N-and O-glycosylation are well known co-and post-translational modifications of
immunoglobulins. Antibody glycosylation on the Fab and Fc portion is known to influence …

Background Diverse varieties of often heterogeneous glycans are ubiquitous in nature. They
play critical roles in recognition events, act as energy stores and provide structural stability at …

Multiple factors influence immunoglobulin G glycosylation, which in turn affect the
glycoproteins' function on eliciting an anti-inflammatory or pro-inflammatory response. It is …

Over the past decades, the genome and proteome have been widely explored for biomarker
discovery and personalized medicine. However, there is still a large need for improved …

Glycan age is a recently developed biomarker based on glycans attached to
immunoglobulin G (IgG). In large population cohorts, glycan age associates well with …

Human lifespan has increased significantly in the last 200 years, emphasizing our need to
age healthily. Insights into molecular mechanisms of aging might allow us to slow down its …

Ageing is linked to a number of changes in how the body and its organs function. On a
molecular level, ageing is associated with a reduction of telomere length, changes in …