Phenotypic plasticity (the ability of a single genotype to produce multiple phenotypes in
response to variation in the environment) is commonplace. Yet its evolutionary significance …

This review describes new developments in the study of transgenerational epigenetic
inheritance, a component of epigenetics. We start by examining the basic concepts of the …

INTRODUCTION Genetic interactions occur when mutations in two or more genes combine
to generate an unexpected phenotype. An extreme negative or synthetic lethal genetic …

Standing watch over the proteome, molecular chaperones are an ancient and evolutionarily
conserved class of proteins that guide the normal folding, intracellular disposition and …

Hsp90 is a dimeric molecular chaperone required for the activation and stabilization of
numerous client proteins many of which are involved in essential cellular processes like …

Organisms are constantly exposed to a wide range of environmental changes, including
both short-term changes during their lifetime and longer-term changes across generations …

Hsp90 is a major molecular chaperone that is expressed abundantly and plays a pivotal role
in assisting correct folding and functionality of its client proteins in cells. The Hsp90 client …

Cells are faced with the task of folding thousands of different polypeptides into a wide range
of conformations. For many proteins, the folding process requires the action of molecular …

Developmental plasticity refers to the property by which the same genotype produces
distinct phenotypes depending on the environmental conditions under which development …

Hsp90 is a molecular chaperone for many signal transducers and may influence evolution
by releasing previously silent genetic variation in response to environmental change. In …