[HTML][HTML] Phage therapy: From biological mechanisms to future directions

SA Strathdee, GF Hatfull, VK Mutalik, RT Schooley - Cell, 2023 - cell.com
Increasing antimicrobial resistance rates have revitalized bacteriophage (phage) research,
the natural predators of bacteria discovered over 100 years ago. In order to use phages …

The human virome: assembly, composition and host interactions

G Liang, FD Bushman - Nature Reviews Microbiology, 2021 - nature.com
The human body hosts vast microbial communities, termed the microbiome. Less well
known is the fact that the human body also hosts vast numbers of different viruses …

The gut virome: A new microbiome component in health and disease

Z Cao, N Sugimura, E Burgermeister, MP Ebert… - …, 2022 - thelancet.com
The human gastrointestinal tract harbours an abundance of viruses, collectively known as
the gut virome. The gut virome is highly heterogeneous across populations and is linked to …

Mutualistic interplay between bacteriophages and bacteria in the human gut

AN Shkoporov, CJ Turkington, C Hill - Nature Reviews Microbiology, 2022 - nature.com
Bacteriophages (phages) are often described as obligate predators of their bacterial hosts,
and phage predation is one of the leading forces controlling the density and distribution of …

[HTML][HTML] The role of diet in shaping human gut microbiota

E Rinninella, E Tohumcu, P Raoul, M Fiorani… - Best Practice & …, 2023 - Elsevier
Gut microbiota plays a fundamental role within human health, and exerts key functions
within the human body. Diet is one of the most powerful modulators of gut microbiota …

Temperate phage-antibiotic synergy eradicates bacteria through depletion of lysogens

AM Al-Anany, R Fatima, AP Hynes - Cell Reports, 2021 - cell.com
There is renewed interest in bacterial viruses (phages) as alternatives to antibiotics. All
phage treatments to date have used virulent phages rather than temperate ones, as these …

Signals triggering prophage induction in the gut microbiota

C Henrot, MA Petit - Molecular Microbiology, 2022 - Wiley Online Library
Compared to bacteria of the gut microbiota, bacteriophages are still poorly characterised,
and their physiological importance is far less known. Temperate phages are probably a …

Factors affecting variation of the human gut phageome

CA Tobin, C Hill, AN Shkoporov - Annual Review of …, 2023 - annualreviews.org
The gut microbiome is a dense and metabolically active consortium of microorganisms and
viruses located in the lower gastrointestinal tract of the human body. Bacteria and their …

Prophage activation in the intestine: insights into functions and possible applications

J Hu, H Ye, S Wang, J Wang, D Han - Frontiers in Microbiology, 2021 - frontiersin.org
Prophage activation in intestinal environments has been frequently reported to affect host
adaptability, pathogen virulence, gut bacterial community composition, and intestinal health …

Distribution of antimicrobial resistance and virulence genes within the prophage-associated regions in nosocomial pathogens

K Kondo, M Kawano, M Sugai - Msphere, 2021 - Am Soc Microbiol
Prophages are often involved in host survival strategies and contribute toward increasing
the genetic diversity of the host genome. Prophages also drive horizontal propagation of …