The cerebral oxygen cascade includes three key stages:(a) convective oxygen delivery
representing the bulk flow of oxygen to the cerebral vascular bed;(b) diffusion of oxygen from …

Inhaled nitric oxide (iNO) acts as a selective pulmonary vasodilator and it is currently
approved by the FDA for the treatment of persistent pulmonary hypertension of the newborn …

Rationale: Secondary brain hypoxia portends significant mortality in ischemic brain
diseases; yet, our understanding of hypoxic ischemic brain injury (HIBI) pathophysiology in …

Genetic information is generally transferred from RNA to protein according to the classic
“Central Dogma”. Here, we made a striking discovery that post-translational modification of a …

The prognosis of cardiac arrest (CA) is dismal despite the ongoing progress in
cardiopulmonary resuscitation (CPR). ginsenoside Rb1 (Gn-Rb1) has been verified to be …

Background Brain injury is the main cause of high mortality and disability after successful
cardiopulmonary resuscitation (CPR) from sudden cardiac arrest (CA). The transient …

S-nitrosylation is a very fundamental post-translational modification of protein and non-
protein thiols due the involvement of it in a variety of cellular processes including …

Background Animal disease models represent the cornerstone in basic cardiac arrest (CA)
research. However, current experimental models of CA and resuscitation in mice are limited …

Nitric oxide (NO) is a key molecule in the biology of human life. NO is involved in the
physiology of organ viability and in the pathophysiology of organ dysfunction, respectively …

Cardiovascular disease is the leading cause of the death for both men and women.
Although baseline heart physiology and the response to disease are known to differ by sex …