Over the past few years, media have popularized the story of the “children of the moon” who
must remain in the dark and avoid exposure to sunlight. 1r3 These children suffer from a rare …

Significance: Oxidative DNA damage is repaired by multiple, overlapping DNA repair
pathways. Accumulating evidence supports the hypothesis that nucleotide excision repair …

A fundamental challenge in human health is the identification of disease-causing genes.
Recently, several studies have tackled this challenge via a network-based approach …

Xeroderma pigmentosum (XP) is a rare DNA repair disorder characterized by increased
susceptibility to UV radiation (UVR)-induced skin pigmentation, skin cancers, ocular surface …

R-loops are structures consisting of an RNA-DNA duplex and an unpaired DNA strand. They
can form during transcription upon nascent RNA “threadback” invasion into the DNA duplex …

Nucleotide-excision repair diseases exhibit cancer, complex developmental disorders and
neurodegeneration. Cancer is the hallmark of xeroderma pigmentosum (XP), and …

Nucleotide excision repair (NER) requires the coordinated sequential assembly and actions
of the involved proteins at sites of DNA damage. Following damage recognition, dual …

Nucleotide excision repair (NER) is a DNA repair pathway that is responsible for removing a
variety of lesions caused by harmful UV light, chemical carcinogens, and environmental …

Loss of a nonenzymatic function of XPG results in defective transcription-coupled repair
(TCR), Cockayne syndrome (CS), and early death, but the molecular basis for these …

ERCC1–XPF is a structure-specific endonuclease required for nucleotide excision repair,
interstrand crosslink repair, and the repair of some double-strand breaks. Mutations in …