In eukaryotic cells, protein and RNA factors involved in genome activities like transcription,
RNA processing, DNA replication, and repair accumulate in self-organizing membraneless …

Multifaceted relations link ribosome biogenesis to cancer. Ribosome biogenesis takes place
in the nucleolus. Clarifying the mechanisms involved in this nucleolar function and its …

The nucleolus and other ribonucleoprotein (RNP) bodies are membrane-less organelles
that appear to assemble through phase separation of their molecular components. However …

G-quadruplex DNAs form four-stranded helical structures and are proposed to play key roles
in different cellular processes. Targeting G-quadruplex DNAs for cancer treatment is a very …

For most intracellular structures with larger than molecular dimensions, little is known about
the connection between underlying molecular activities and higher order organization such …

This work reviews nuclear compartments, defined broadly to include distinct nuclear
structures, bodies, and chromosome domains. It first summarizes original cytological …

Deregulated ribosomal RNA synthesis is associated with uncontrolled cancer cell
proliferation. RNA polymerase (Pol) I, the multiprotein complex that synthesizes rRNA, is …

Abstract RNA polymerase I (Pol I) transcription of ribosomal RNA genes (rDNA) is tightly
regulated downstream of oncogenic pathways, and its dysregulation is a common feature in …

Nuclear architecture—the spatial arrangement of chromosomes and other nuclear
components—provides a framework for organizing and regulating the diverse functional …

Hallmark deregulated signaling in cancer cells drives excessive ribosome biogenesis within
the nucleolus, which elicits unbridled cell growth and proliferation. The rate-limiting step of …