Lgr5 was originally discovered as a common Wnt target gene in adult intestinal crypts and
colon cancer. It was subsequently identified as an exquisite marker of multiple Wnt-driven …

The four vertebrate R-spondin proteins are secreted agonists of the canonical Wnt/β-catenin
signaling pathway. These proteins are approximately 35 kDa, and are characterized by two …

The Wnt/β-catenin signaling system plays essential roles in embryonic development and in
the self-renewal and maintenance of adult stem cells. R-spondins (RSPOs) are a group of …

Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …

Tumor necrosis factor (TNF) superfamily member 11 (TNFSF11, also known as RANKL)
regulates multiple physiological or pathological functions, including osteoclast differentiation …

Molecular markers are used to characterize and track adult stem cells. Colon cancer
research has led to the identification of 2 related receptors, leucine-rich repeat–containing …

Therapies targeting immune checkpoints have shown great clinical potential in a subset of
patients with cancer but may be hampered by a failure to reverse the immunosuppressive …

After its discovery as oncogen and morphogen, studies on Wnt focused initially on its role in
animal development. With the finding that the colorectal tumour suppressor gene APC is a …

Low bone mineral density (BMD) is used as a parameter of osteoporosis. Genome-wide
association studies of BMD have hitherto focused on BMD as a quantitative trait, yielding …

Rationale: Macrophages are critically involved in wound healing following myocardial
infarction (MI). Lgr4, a member of LGR (leucine-rich repeat-containing G protein-coupled …