Apelin and apela (ELABELA/ELA/Toddler) are two peptide ligands for a class A G-protein-
coupled receptor named the apelin receptor (AR/APJ/APLNR). Ligand-AR interactions have …

A large body of evidence indicates that genome annotation pipelines have biased our view
of coding sequences because they generally undersample small proteins and peptides. The …

Abstract ELABELA (ELA), a 32-residue hormone peptide abundantly expressed in adult
kidneys, has been identified as a novel endogenous ligand for APJ/Apelin receptor. The aim …

Heart failure (HF) is a growing epidemic with high morbidity and mortality at an international
scale. The apelin–APJ receptor pathway has been implicated in HF, making it a promising …

Technological advances promise unprecedented opportunities for whole exome sequencing
and proteomic analyses of populations. Currently, data from genome and exome …

The apelinergic system comprises two peptide ligands, apelin and ELABELA, and their
cognate G-protein-coupled receptor, the apelin receptor APJ. Apelin is a peptide that was …

Apelin receptor (APJR) is a class A peptide (apelin) binding G protein-coupled receptor
(GPCR) that plays a significant role in regulating blood pressure, cardiac output, and …

G‐protein‐coupled receptors (GPCRs) are recognized as the largest protein receptor
superfamily, which are widely distributed in various tissues and organs. In addition, GPCRs …

Elabela (ELA; also called Apela and Toddler) is one of the recently discovered ligand
among the two endogenous peptide ligands (Apelin and Elabela) of the apelin receptor …

Introduction Renal ischemia/reperfusion injury (IRI) is the most common cause of acute
kidney injury (AKI), and patients with AKI have a high rate of mortality. Apelin is a therapeutic …