Reactive oxygen species (ROS) serve as cell signaling molecules for normal biologic
processes. However, the generation of ROS can also provoke damage to multiple cellular …

In 2004, 12.5 percent of births in the United States were preterm; that is, born at less than 37
completed weeks of gestation. This rate has increased steadily in the past decade. There …

Germinal matrix–intraventricular hemorrhage (GMH-IVH) is the most common variety of
neonatal intracranial hemorrhage and is characteristic of the premature infant. This form of …

Bronchopulmonary dysplasia is a chronic lung disease that affects premature babies and
contributes to their morbidity and mortality. Improved survival of very immature infants has …

Persistent pulmonary hypertension of the newborn (PPHN) is a syndrome of failed
circulatory adaptation at birth, seen in about 2/1000 live born infants. While it is mostly seen …

Objective: Stroke risk due to intracranial atherosclerosis increases with degree of arterial
stenosis. We evaluated the previously unexplored role of collaterals in modifying stroke risk …

With increasing numbers of extremely premature infants surviving, the outcome for these
infants has generated much interest and controversy. This article reviews recent progress in …

Background Inhaled nitric oxide (iNO) is effective in term infants with hypoxic respiratory
failure. The pathophysiology of respiratory failure and the potential risks of iNO differ …

BACKGROUND. Neurodevelopmental impairment of extremely low birth weight infants
increased in the 1990s. Modern therapeutic changes may have influenced more recent …

Background Bronchopulmonary dysplasia in premature infants is associated with prolonged
hospitalization, as well as abnormal pulmonary and neurodevelopmental outcome. In …