Experimental infection of human volunteers
M Roestenberg, MA Hoogerwerf… - The Lancet Infectious …, 2018 - thelancet.com
Controlled human infection (CHI) trials, in which healthy volunteers are experimentally
infected, can accelerate the development of novel drugs and vaccines for infectious …
infected, can accelerate the development of novel drugs and vaccines for infectious …
Controlled human malaria infection: applications, advances, and challenges
Controlled human malaria infection (CHMI) entails deliberate infection with malaria
parasites either by mosquito bite or by direct injection of sporozoites or parasitized …
parasites either by mosquito bite or by direct injection of sporozoites or parasitized …
Examining the human infectious reservoir for Plasmodium falciparum malaria in areas of differing transmission intensity
A detailed understanding of the human infectious reservoir is essential for improving malaria
transmission-reducing interventions. Here we report a multi-regional assessment of …
transmission-reducing interventions. Here we report a multi-regional assessment of …
Prime-boost vaccination with chimpanzee adenovirus and modified vaccinia Ankara encoding TRAP provides partial protection against Plasmodium falciparum …
C Ogwang, D Kimani, NJ Edwards, R Roberts… - Science translational …, 2015 - science.org
Protective immunity to the liver stage of the malaria parasite can be conferred by vaccine-
induced T cells, but no subunit vaccination approach based on cellular immunity has shown …
induced T cells, but no subunit vaccination approach based on cellular immunity has shown …
Malaria diagnosis for malaria elimination
PA Zimmerman, RE Howes - Current opinion in infectious …, 2015 - journals.lww.com
Malaria diagnosis for malaria elimination : Current Opinion in Infectious Diseases Malaria
diagnosis for malaria elimination : Current Opinion in Infectious Diseases Log in or Register …
diagnosis for malaria elimination : Current Opinion in Infectious Diseases Log in or Register …
Species and genotype diversity of Plasmodium in malaria patients from Gabon analysed by next generation sequencing
A Lalremruata, S Jeyaraj, T Engleitner, F Joanny… - Malaria journal, 2017 - Springer
Abstract Background Six Plasmodium species are known to naturally infect humans. Mixed
species infections occur regularly but morphological discrimination by microscopy is difficult …
species infections occur regularly but morphological discrimination by microscopy is difficult …
First international external quality assessment scheme of nucleic acid amplification tests for the detection of Schistosoma and soil-transmitted helminths, including …
P Cools, L van Lieshout, R Koelewijn… - PLoS neglected …, 2020 - journals.plos.org
Background Nucleic acid amplification tests (NAATs) are increasingly being used as
diagnostic tools for soil-transmitted helminths (STHs; Ascaris lumbricoides, Trichuris …
diagnostic tools for soil-transmitted helminths (STHs; Ascaris lumbricoides, Trichuris …
[HTML][HTML] Beyond blood smears: qualification of Plasmodium 18S rRNA as a biomarker for controlled human malaria infections
AM Seilie, M Chang, AE Hanron… - The American journal …, 2019 - ncbi.nlm.nih.gov
18S rRNA is a biomarker that provides an alternative to thick blood smears in controlled
human malaria infection (CHMI) trials. We reviewed data from CHMI trials at non-endemic …
human malaria infection (CHMI) trials. We reviewed data from CHMI trials at non-endemic …
Substantial asymptomatic submicroscopic Plasmodium carriage during dry season in low transmission areas in Senegal: Implications for malaria control and …
Background In the progress towards malaria elimination, the accurate diagnosis of low-
density asymptomatic infections is critical. Low-density asymptomatic submicroscopic …
density asymptomatic infections is critical. Low-density asymptomatic submicroscopic …
A nested real-time PCR assay for the quantification of Plasmodium falciparum DNA extracted from dried blood spots
Background As public health efforts seek to eradicate malaria, there has been an emphasis
on eliminating low-density parasite reservoirs in asymptomatic carriers. As such, diagnosing …
on eliminating low-density parasite reservoirs in asymptomatic carriers. As such, diagnosing …