Abstract Hypoxia-inducible factor-1 (HIF-1) has been recognized as an important cancer
drug target. Many recent studies have provided convincing evidences of strong correlation …

Vitamin C (Ascorbic Acid), the antiscorbutic vitamin, cannot be synthesized by humans and
other primates, and has to be obtained from diet. Ascorbic acid is an electron donor and acts …

The KDM5 family of histone demethylases catalyzes the demethylation of histone H3 on
lysine 4 (H3K4) and is required for the survival of drug-tolerant persister cancer cells (DTPs) …

Many gene sequences in eukaryotic genomes encode entire proteins or large segments of
proteins that lack a well-structured three-dimensional fold. Disordered regions can be highly …

The transcription factor HIF (hypoxia-inducible factor) has a central role in oxygen
homeostasis in animals ranging from nematode worms to man. Recent studies have shown …

There have been significant advances in our understanding of mononuclear nonheme iron
oxygenases since our 1996 Chemical Reviews article, 1 promoted in large part by the many …

Hypoxia is a fundamental stimulus that impacts cells, tissues, organs, and physiological
systems. The discovery of hypoxia-inducible factor-1 (HIF-1) and subsequent identification of …

In this review, we discuss recent advances made on histone methylation and its diverse
functions in regulating gene expression. Methylation of histone polypeptides might be static …

Histone methylation has important roles in regulating gene expression and forms part of the
epigenetic memory system that regulates cell fate and identity. Enzymes that directly remove …

Fe (II)/α-ketoglutarate (αKG)-dependent hydroxylases catalyze an amazing diversity of
reactions that result in protein side-chain modifications, repair of alkylated DNA/RNA …