Nonhomologous end joining (NHEJ) refers to a set of genome maintenance pathways in
which two DNA double-strand break (DSB) ends are (re) joined by apposition, processing …

DNA ligases are required for DNA replication, repair, and recombination. In eukaryotes,
there are three families of ATP-dependent DNA ligases. Members of the DNA ligase I and IV …

DNA double-strand breaks (DSBs) are a highly cytotoxic form of DNA damage and the
incorrect repair of DSBs is linked to carcinogenesis,. The conserved error-prone non …

BRCA1 C-terminal (BRCT) domains are integral signaling modules in the DNA damage
response (DDR). Aside from their established roles as phospho-peptide binding modules …

Pathogenic mutation in BRCA1 gene is one of the most penetrant genetic predispositions
towards cancer. Identification of the mutation provides important aspect in prevention and …

Summary The Mre11/Rad50/Nbs1 protein complex plays central enzymatic and signaling
roles in the DNA-damage response. Nuclease (Mre11) and scaffolding (Rad50) components …

DNA non-homologous end-joining (NHEJ) is a major mechanism for repairing DNA double-
stranded (ds) breaks in mammalian cells. Here, we characterize the interaction between two …

Nonhomologous end joining (NHEJ) is an important DNA double-strand-break (DSB) repair
pathway that requires three protein complexes in Saccharomyces cerevisiae: the Ku …

Homologous integration of a foreign DNA segment into a chromosomal target sequence
enables precise disruption or replacement of genes of interest and provides an effective …

Nonhomologous end-joining represents the major pathway used by human cells to repair
DNA double-strand breaks. It relies on the XRCC4/DNA ligase IV complex to reseal DNA …