Ageing and rejuvenation of tissue stem cells and their niches
Most adult organs contain regenerative stem cells, often organized in specific niches. Stem
cell function is critical for tissue homeostasis and repair upon injury, and it is dependent on …
cell function is critical for tissue homeostasis and repair upon injury, and it is dependent on …
[HTML][HTML] Hematopoietic Stem Cells Focus: Inflammation as a regulator of hematopoietic stem cell function in disease, aging, and clonal selection
F Caiado, EM Pietras, MG Manz - The Journal of experimental …, 2021 - ncbi.nlm.nih.gov
Inflammation is an evolutionarily selected defense response to infection or tissue damage
that involves activation and consumption of immune cells in order to reestablish and …
that involves activation and consumption of immune cells in order to reestablish and …
Stromal niche inflammation mediated by IL-1 signalling is a targetable driver of haematopoietic ageing
Haematopoietic ageing is marked by a loss of regenerative capacity and skewed
differentiation from haematopoietic stem cells (HSCs), leading to impaired blood production …
differentiation from haematopoietic stem cells (HSCs), leading to impaired blood production …
[HTML][HTML] Targeting immune dysfunction in aging
Human aging is a multifactorial phenomenon that affects numerous organ systems and
cellular processes, with the immune system being one of the most dysregulated …
cellular processes, with the immune system being one of the most dysregulated …
Frailty, aging, and periodontal disease: Basic biologic considerations
D Clark, E Kotronia, SE Ramsay - Periodontology 2000, 2021 - Wiley Online Library
Aging is associated with the development of disease. Periodontal disease is one of the
many diseases and conditions that increase in prevalence with age. In addition to the …
many diseases and conditions that increase in prevalence with age. In addition to the …
Inflammation resolution: implications for atherosclerosis
AC Doran - Circulation research, 2022 - Am Heart Assoc
Resolution is an active and highly coordinated process that occurs in response to
inflammation to limit tissue damage and promote repair. When the resolution program fails …
inflammation to limit tissue damage and promote repair. When the resolution program fails …
Hematopoietic stem cells through the ages: A lifetime of adaptation to organismal demands
M Kasbekar, CA Mitchell, MA Proven, E Passegué - Cell Stem Cell, 2023 - cell.com
Hematopoietic stem cells (HSCs), which govern the production of all blood lineages,
transition through a series of functional states characterized by expansion during fetal …
transition through a series of functional states characterized by expansion during fetal …
Neutrophils in aging and aging‐related pathologies
K Van Avondt, JK Strecker, C Tulotta… - Immunological …, 2023 - Wiley Online Library
Over the past millennia, life expectancy has drastically increased. While a mere 25 years
during Bronze and Iron ages, life expectancy in many European countries and in Japan is …
during Bronze and Iron ages, life expectancy in many European countries and in Japan is …
IL-1 mediates microbiome-induced inflammaging of hematopoietic stem cells in mice
LV Kovtonyuk, F Caiado… - Blood, The Journal …, 2022 - ashpublications.org
Aging is associated with impaired hematopoietic and immune function caused in part by
decreased fitness in the hematopoietic stem cell (HSC) population and an increased …
decreased fitness in the hematopoietic stem cell (HSC) population and an increased …
Aging drives Tet2+/− clonal hematopoiesis via IL-1 signaling
F Caiado, LV Kovtonyuk, NG Gonullu, J Fullin… - Blood, 2023 - ashpublications.org
Clonal hematopoiesis of indeterminate potential (CHIP), also referred to as aging-related
clonal hematopoiesis, is defined as an asymptomatic clonal expansion of mutant mature …
clonal hematopoiesis, is defined as an asymptomatic clonal expansion of mutant mature …