[HTML][HTML] Noradrenergic regulation of cue-guided decision making and impulsivity is doubly dissociable across frontal brain regions

CS Chernoff, TJ Hynes, JD Schumacher… - …, 2024 - Springer
Rationale Win-paired stimuli can promote risk taking in experimental gambling paradigms in
both rats and humans. We previously demonstrated that atomoxetine, a noradrenaline …

The neuropharmacological profile of interval responding during operant tasks

R Lalonde, C Strazielle - Naunyn-Schmiedeberg's Archives of …, 2024 - Springer
Responses occurring during intervals of operant tasks have been subdivided as interim,
facultative, and terminal, depending on the time between response onset and reward …

Win-paired cues modulate the effect of dopamine neuron sensitization on decision making and cocaine self-administration: divergent effects across sex

TJ Hynes, CS Chernoff, KM Hrelja, TL Maric… - Biological …, 2024 - Elsevier
Background Both psychostimulant use and engagement with probabilistic schedules of
reward sensitize the mesocorticolimbic dopamine (DA) system. Such behaviors may act …

Dopamine activity in the nigrostriatal pathway alters cue‐induced risky choice patterns in female rats

BA Hathaway, A Li, HG Brodie… - European Journal of …, 2024 - Wiley Online Library
Deficits in cost/benefit decision making is a critical risk factor for gambling disorder. Reward‐
paired cues may play an important role, as these stimuli can enhance risk preference in rats …

An opponent striatal circuit for distributional reinforcement learning

AS Lowet, Q Zheng, M Meng, S Matias, J Drugowitsch… - bioRxiv, 2024 - biorxiv.org
Machine learning research has achieved large performance gains on a wide range of tasks
by expanding the learning target from mean rewards to entire probability distributions of …

[HTML][HTML] Sexually dimorphic development of the mesolimbic dopamine system is associated with nuanced sensitivity to adolescent alcohol use

AM Asarch, LC Kruse, AG Schindler… - Frontiers in Behavioral …, 2023 - frontiersin.org
Alcohol use remains a major public health concern and is especially prevalent during
adolescence. Adolescent alcohol use has been linked to several behavioral abnormalities in …

[PDF][PDF] Dissociating the role of prefrontal noradrenaline signaling in cost-benefit decision making and impulsive action

C Chernoff - 2023 - open.library.ubc.ca
Win-paired stimuli can promote risk taking on experimental gambling paradigms in both rats
and humans. We previously demonstrated that atomoxetine, a noradrenaline reuptake …

Towards a better understanding of the bidirectional relationship between decision-making and addiction vulnerability

KM Hrelja - 2024 - open.library.ubc.ca
Impaired decision-making is recognized as a diagnostic criterion for many different
psychiatric disorders including gambling disorder and substance use disorders. Habit …