Safety assessment of graphene-based materials: focus on human health and the environment

B Fadeel, C Bussy, S Merino, E Vázquez, E Flahaut… - ACS …, 2018 - ACS Publications
Graphene and its derivatives are heralded as “miracle” materials with manifold applications
in different sectors of society from electronics to energy storage to medicine. The increasing …

Biocompatibility of nanomaterials and their immunological properties

TR Kyriakides, A Raj, TH Tseng, H Xiao… - Biomedical …, 2021 - iopscience.iop.org
Nanomaterials (NMs) have revolutionized multiple aspects of medicine by enabling novel
sensing, diagnostic, and therapeutic approaches. Advancements in processing and …

[HTML][HTML] Photonic and magnetic materials for on-demand local drug delivery

I Armenia, CC Ayllón, BT Herrero, F Bussolari… - Advanced drug delivery …, 2022 - Elsevier
Nanomedicine has been considered a promising tool for biomedical research and clinical
practice in the 21st century because of the great impact nanomaterials could have on human …

[HTML][HTML] Understanding the bidirectional interactions between two-dimensional materials, microorganisms, and the immune system

G Peng, B Fadeel - Advanced drug delivery reviews, 2022 - Elsevier
Abstract Two-dimensional (2D) materials such as the graphene-based materials, transition
metal dichalcogenides, transition metal carbides and nitrides (MXenes), black phosphorus …

Neutrophils and macrophages as targets for development of nanotherapeutics in inflammatory diseases

Y Su, J Gao, P Kaur, Z Wang - Pharmaceutics, 2020 - mdpi.com
Neutrophils and macrophages are major components of innate systems, playing central
roles in inflammation responses to infections and tissue injury. If they are out of control …

Recent insights on indirect mechanisms in developmental toxicity of nanomaterials

BB Dugershaw, L Aengenheister, SSK Hansen… - Particle and Fibre …, 2020 - Springer
Background Epidemiological and animal studies provide compelling indications that
environmental and engineered nanomaterials (NMs) pose a risk for pregnancy, fetal …

[HTML][HTML] NanoSolveIT Project: Driving nanoinformatics research to develop innovative and integrated tools for in silico nanosafety assessment

A Afantitis, G Melagraki, P Isigonis, A Tsoumanis… - Computational and …, 2020 - Elsevier
Nanotechnology has enabled the discovery of a multitude of novel materials exhibiting
unique physicochemical (PChem) properties compared to their bulk analogues. These …

Hide and seek: Nanomaterial interactions with the immune system

B Fadeel - Frontiers in immunology, 2019 - frontiersin.org
Engineered nanomaterials hold promise for a wide range of applications in medicine.
However, safe use of nanomaterials requires that interactions with biological systems, not …

Interaction between nanomaterials and the innate immune system across evolution

D Boraschi, L Canesi, D Drobne… - Biological …, 2023 - Wiley Online Library
Interaction of engineered nanomaterials (ENMs) with the immune system mainly occurs with
cells and molecules of innate immunity, which are present in interface tissues of living …

Hydroxyapatite nanoparticles promote TLR4 agonist-mediated anti-tumor immunity through synergically enhanced macrophage polarization

R Wang, Y Hua, H Wu, J Wang, Y Xiao, X Chen, Q Ao… - Acta Biomaterialia, 2023 - Elsevier
Macrophages represent the most prevalent immune cells in the tumor micro-environment,
making them an appealing target for tumor immunotherapy. One of our previous studies …