The century following the determination of the first crystal structure by the Braggs 1 has
yielded encyclopedic precise information on molecular geometry. The interatomic distances …

The assembly of individual proteins into functional complexes is fundamental to nearly all
biological processes. In recent decades, many thousands of homomeric and heteromeric …

Assessing the viability of an amorphous formulation strategy is of great importance in an era
of drug discovery where a large percentage of new molecules have solubility limited …

The importance of amorphous pharmaceutical solids lies in their useful properties, common
occurrence, and physicochemical instability relative to corresponding crystals. Some …

Polymorphism in molecular crystals is a prevalent phenomenon and is of great interest to the
pharmaceutical community. The solid-state form is a key quality attribute of a crystalline …

Developability molecule assessment is a key interfacial capability across the
biopharmaceutical industry, screening and staging molecules discovered by medicinal …

The diversity of solid-state forms that an active pharmaceutical ingredient (API) may attain
relies on the repertoire of non-covalent interactions and molecular assemblies, the range of …

Highlights•Degraders are an emerging modality which fall into the 'beyond rule of
5'space.•Poor permeability and solubility are critical features limiting oral absorption.• …

For decades, carbamazepine (CBZ) has served as a model compound for groups engaged
in the study of crystal polymorphism. Despite considerable effort, crystal structures for only …

Polymorphs are different crystalline modifications of the same chemical substance. When
different conformers of the same molecule occur in different crystal forms, the phenomenon …