Regulation of filaggrin, loricrin, and involucrin by IL-4, IL-13, IL-17A, IL-22, AHR, and NRF2: pathogenic implications in atopic dermatitis

M Furue - International journal of molecular sciences, 2020 - mdpi.com
Atopic dermatitis (AD) is an eczematous, pruritic skin disorder with extensive barrier
dysfunction and elevated interleukin (IL)-4 and IL-13 signatures. The barrier dysfunction …

Immunology of COVID‐19: mechanisms, clinical outcome, diagnostics, and perspectives—a report of the European Academy of Allergy and Clinical Immunology …

M Sokolowska, ZM Lukasik, I Agache, CA Akdis… - Allergy, 2020 - Wiley Online Library
With the worldwide spread of the novel severe acute respiratory syndrome coronavirus‐2
(SARS‐CoV‐2) resulting in declaration of a pandemic by the World Health Organization …

ADAM10 and ADAM17 promote SARS‐CoV‐2 cell entry and spike protein‐mediated lung cell fusion

G Jocher, V Grass, SK Tschirner, L Riepler… - EMBO …, 2022 - embopress.org
The severe‐acute‐respiratory‐syndrome‐coronavirus‐2 (SARS‐CoV‐2) is the causative
agent of COVID‐19, but host cell factors contributing to COVID‐19 pathogenesis remain only …

Distinct spatial and temporal roles for Th1, Th2, and Th17 cells in asthma

W Luo, J Hu, W Xu, J Dong - Frontiers in Immunology, 2022 - frontiersin.org
Immune response in the asthmatic respiratory tract is mainly driven by CD4+ T helper (Th)
cells, represented by Th1, Th2, and Th17 cells, especially Th2 cells. Asthma is a …

More than just a barrier: the immune functions of the airway epithelium in asthma pathogenesis

A Frey, LP Lunding, JC Ehlers, M Weckmann… - Frontiers in …, 2020 - frontiersin.org
Allergic bronchial asthma is a chronic disease of the airways that is characterized by
symptoms like respiratory distress, chest tightness, wheezing, productive cough, and acute …

MERS-CoV and H5N1 influenza virus antagonize antigen presentation by altering the epigenetic landscape

VD Menachery, A Schäfer… - Proceedings of the …, 2018 - National Acad Sciences
Convergent evolution dictates that diverse groups of viruses will target both similar and
distinct host pathways to manipulate the immune response and improve infection. In this …

Airway basal cells, protectors of epithelial walls in health and respiratory diseases

E Ruysseveldt, K Martens, B Steelant - Frontiers in Allergy, 2021 - frontiersin.org
The airway epithelium provides a critical barrier to the outside environment. When its
integrity is impaired, epithelial cells and residing immune cells collaborate to exclude …

T-helper cells and their cytokines in pathogenesis and treatment of asthma

T Ji, H Li - Frontiers in Immunology, 2023 - frontiersin.org
Prosperous advances in understanding the cellular and molecular mechanisms of chronic
inflammation and airway remodeling in asthma have been made over the past several …

Attenuation of SARS‐CoV‐2 replication and associated inflammation by concomitant targeting of viral and host cap 2'‐O‐ribose methyltransferases

V Bergant, S Yamada, V Grass, Y Tsukamoto… - The EMBO …, 2022 - embopress.org
The SARS‐CoV‐2 infection cycle is a multistage process that relies on functional
interactions between the host and the pathogen. Here, we repurposed antiviral drugs …

The IL‐13/periostin/IL‐24 pathway causes epidermal barrier dysfunction in allergic skin inflammation

Y Mitamura, S Nunomura, Y Nanri, M Ogawa… - Allergy, 2018 - Wiley Online Library
Background Barrier dysfunction is an important feature of atopic dermatitis (AD) in which IL‐
4 and IL‐13, signature type 2 cytokines, are involved. Periostin, a matricellular protein …