Plant pan-genomes are the new reference

PE Bayer, AA Golicz, A Scheben, J Batley, D Edwards - Nature plants, 2020 - nature.com
Recent years have seen a surge in plant genome sequencing projects and the comparison
of multiple related individuals. The high degree of genomic variation observed led to the …

Pan-genomics in the human genome era

RM Sherman, SL Salzberg - Nature Reviews Genetics, 2020 - nature.com
Since the early days of the genome era, the scientific community has relied on a single
'reference'genome for each species, which is used as the basis for a wide range of genetic …

[HTML][HTML] Eight high-quality genomes reveal pan-genome architecture and ecotype differentiation of Brassica napus

JM Song, Z Guan, J Hu, C Guo, Z Yang, S Wang, D Liu… - Nature plants, 2020 - nature.com
Rapeseed (Brassica napus) is the second most important oilseed crop in the world but the
genetic diversity underlying its massive phenotypic variations remains largely unexplored …

[HTML][HTML] Pan-genome analysis highlights the extent of genomic variation in cultivated and wild rice

Q Zhao, Q Feng, H Lu, Y Li, A Wang, Q Tian, Q Zhan… - Nature …, 2018 - nature.com
The rich genetic diversity in Oryza sativa and Oryza rufipogon serves as the main sources in
rice breeding. Large-scale resequencing has been undertaken to discover allelic variants in …

Phased diploid genome assembly with single-molecule real-time sequencing

CS Chin, P Peluso, FJ Sedlazeck, M Nattestad… - Nature …, 2016 - nature.com
While genome assembly projects have been successful in many haploid and inbred
species, the assembly of noninbred or rearranged heterozygous genomes remains a major …

[HTML][HTML] Multi-parent populations in crops: a toolbox integrating genomics and genetic mapping with breeding

MF Scott, O Ladejobi, S Amer, AR Bentley, J Biernaskie… - Heredity, 2020 - nature.com
Crop populations derived from experimental crosses enable the genetic dissection of
complex traits and support modern plant breeding. Among these, multi-parent populations …

[HTML][HTML] Sequencing of allotetraploid cotton (Gossypium hirsutum L. acc. TM-1) provides a resource for fiber improvement

T Zhang, Y Hu, W Jiang, L Fang, X Guan, J Chen… - Nature …, 2015 - nature.com
Upland cotton is a model for polyploid crop domestication and transgenic improvement.
Here we sequenced the allotetraploid Gossypium hirsutum L. acc. TM-1 genome by …

[HTML][HTML] 1,135 genomes reveal the global pattern of polymorphism in Arabidopsis thaliana

C Alonso-Blanco, J Andrade, C Becker, F Bemm… - Cell, 2016 - cell.com
Arabidopsis thaliana serves as a model organism for the study of fundamental physiological,
cellular, and molecular processes. It has also greatly advanced our understanding of …

[HTML][HTML] Super-pangenome by integrating the wild side of a species for accelerated crop improvement

AW Khan, V Garg, M Roorkiwal, AA Golicz… - Trends in plant …, 2020 - cell.com
The pangenome provides genomic variations in the cultivated gene pool for a given species.
However, as the crop's gene pool comprises many species, especially wild relatives with …

[HTML][HTML] Determination and inference of eukaryotic transcription factor sequence specificity

MT Weirauch, A Yang, M Albu, AG Cote… - Cell, 2014 - cell.com
Transcription factor (TF) DNA sequence preferences direct their regulatory activity, but are
currently known for only∼ 1% of eukaryotic TFs. Broadly sampling DNA-binding domain …