BDNF signaling in context: From synaptic regulation to psychiatric disorders
Brain-derived neurotrophic factor (BDNF) is a neuropeptide that plays numerous important
roles in synaptic development and plasticity. While its importance in fundamental physiology …
roles in synaptic development and plasticity. While its importance in fundamental physiology …
Ketamine versus ECT for nonpsychotic treatment-resistant major depression
Background Electroconvulsive therapy (ECT) and subanesthetic intravenous ketamine are
both currently used for treatment-resistant major depression, but the comparative …
both currently used for treatment-resistant major depression, but the comparative …
Single-dose psilocybin-assisted therapy in major depressive disorder: A placebo-controlled, double-blind, randomised clinical trial
R von Rotz, EM Schindowski, J Jungwirth… - …, 2023 - thelancet.com
Background Psilocybin has been suggested as a novel, rapid-acting treatment for
depression. Two consecutive doses have been shown to markedly decrease symptom …
depression. Two consecutive doses have been shown to markedly decrease symptom …
Psychedelics reopen the social reward learning critical period
R Nardou, E Sawyer, YJ Song, M Wilkinson… - Nature, 2023 - nature.com
Psychedelics are a broad class of drugs defined by their ability to induce an altered state of
consciousness,. These drugs have been used for millennia in both spiritual and medicinal …
consciousness,. These drugs have been used for millennia in both spiritual and medicinal …
The 2020 Royal Australian and New Zealand College of Psychiatrists clinical practice guidelines for mood disorders
Objectives: To provide advice and guidance regarding the management of mood disorders,
derived from scientific evidence and supplemented by expert clinical consensus to formulate …
derived from scientific evidence and supplemented by expert clinical consensus to formulate …
New and emerging approaches to treat psychiatric disorders
Psychiatric disorders are highly prevalent, often devastating diseases that negatively impact
the lives of millions of people worldwide. Although their etiological and diagnostic …
the lives of millions of people worldwide. Although their etiological and diagnostic …
[HTML][HTML] Psychedelics and neuroplasticity: a systematic review unraveling the biological underpinnings of psychedelics
Clinical studies suggest the therapeutic potential of psychedelics, including ayahuasca,
DMT, psilocybin, and LSD, in stress-related disorders. These substances induce cognitive …
DMT, psilocybin, and LSD, in stress-related disorders. These substances induce cognitive …
Comparative efficacy of racemic ketamine and esketamine for depression: a systematic review and meta-analysis
Background Ketamine appears to have a therapeutic role in certain mental disorders, most
notably depression. However, the comparative performance of different formulations of …
notably depression. However, the comparative performance of different formulations of …
Sustained antidepressant effect of ketamine through NMDAR trapping in the LHb
Ketamine, an N-methyl-d-aspartate receptor (NMDAR) antagonist, has revolutionized the
treatment of depression because of its potent, rapid and sustained antidepressant effects …
treatment of depression because of its potent, rapid and sustained antidepressant effects …
Efficacy and safety of ketamine vs electroconvulsive therapy among patients with major depressive episode: a systematic review and meta-analysis
Importance Whether ketamine is as effective as electroconvulsive therapy (ECT) among
patients with major depressive episode remains unknown. Objective To systematically …
patients with major depressive episode remains unknown. Objective To systematically …