Desmosomal cadherins are a recent evolutionary innovation that make up the adhesive core
of highly specialized intercellular junctions called desmosomes. Desmosomal cadherins …

Desmosomes are intercellular junctions, which preserve tissue integrity during homeostatic
and stress conditions. These functions rely on their unique structural properties, which …

NEDD8 (Neural precursor cell expressed developmentally downregulated protein 8) is an
ubiquitin-like protein that is covalently attached to a lysine residue of a protein substrate …

Biochemical methods can reveal stable protein‐protein interactions occurring within cells,
but the ability to observe transient events and to visualize the subcellular localization of …

Desmosomes are relatives of ancient cadherin-based junctions, which emerged late in
evolution to ensure the structural integrity of vertebrate tissues by coupling the intermediate …

Tissue integrity is crucial for maintaining the homeostasis of living organisms. Abnormalities
that affect sites of cell-cell contact can cause a variety of debilitating disorders. The …

While classic cadherin-actin connections in adherens junctions (AJs) have ancient origins,
intermediate filament (IF) linkages with desmosomal cadherins arose in vertebrate …

Neddylation, a posttranslational protein modification, refers to the specific conjugation of
NEDD8 to substrates, which is of great significance to various biological processes. Besides …

Cellular receptors regulate physiological responses by interacting with ligands, thus playing
a crucial role in intercellular communication. Receptors are categorized on the basis of their …

Arrhythmogenic cardiomyopathy (AC) is a common cause of sudden cardiac arrest and
death in young adults. It can be induced by different types of mutations throughout the …