Genome-wide association analyses of post-traumatic stress disorder and its symptom subdomains in the Million Veteran Program
We conducted genome-wide association analyses of over 250,000 participants of European
(EUR) and African (AFR) ancestry from the Million Veteran Program using electronic health …
(EUR) and African (AFR) ancestry from the Million Veteran Program using electronic health …
The comorbidity of post-traumatic stress disorder (PTSD) and substance use disorders
Post-traumatic stress disorder (PTSD) and substance use disorders (SUDs) frequently co-
occur. Among individuals seeking treatment for SUDs, it is estimated that 30–50% meet …
occur. Among individuals seeking treatment for SUDs, it is estimated that 30–50% meet …
Factors contributing to the escalation of alcohol consumption
Understanding factors that contribute to the escalation of alcohol consumption is key to
understanding how an individual transitions from non/social drinking to AUD and to …
understanding how an individual transitions from non/social drinking to AUD and to …
Behavioral and accumbens synaptic plasticity induced by cues associated with restraint stress
C Garcia-Keller, JS Carter, A Kruyer… - …, 2021 - nature.com
Exposure to acute stress can increase vulnerability to develop or express many psychiatric
disorders, including post-traumatic stress disorder. We hypothesized that stress-induced …
disorders, including post-traumatic stress disorder. We hypothesized that stress-induced …
Chronic ethanol consumption exacerbates future stress‐enhanced fear learning, an effect mediated by dorsal hippocampal astrocytes
GA Barkell, SV Parekh, JE Paniccia… - Alcoholism: Clinical …, 2022 - Wiley Online Library
Background Alcohol use disorder (AUD) and post‐traumatic stress disorder (PTSD) are
highly comorbid, yet there is a lack of preclinical research investigating how prior ethanol …
highly comorbid, yet there is a lack of preclinical research investigating how prior ethanol …
Importance of sex and trauma context on circulating cytokines and amygdalar GABAergic signaling in a comorbid model of posttraumatic stress and alcohol use …
Alcohol use disorder (AUD) and anxiety disorders are frequently comorbid and share
mechanisms that could be therapeutic targets. To facilitate mechanistic studies, we adapted …
mechanisms that could be therapeutic targets. To facilitate mechanistic studies, we adapted …
Chronic heroin use disorder and the brain: current evidence and future implications
The incidence of chronic heroin use disorder, including overdose deaths, has reached
epidemic proportions. Here we summarise and evaluate our knowledge of the relationship …
epidemic proportions. Here we summarise and evaluate our knowledge of the relationship …
Intrusive thinking: Circuit and synaptic mechanisms of a transdiagnostic psychiatric symptom
PW Kalivas, SL Gourley, MP Paulus - Neuroscience & Biobehavioral …, 2023 - Elsevier
Spontaneous thought is an adaptive cognitive process that can produce novel and insightful
thought sequences useful in guiding future behavior. In many psychiatric disorders …
thought sequences useful in guiding future behavior. In many psychiatric disorders …
Oxytocin reduces sensitized stress–induced alcohol relapse in a model of posttraumatic stress disorder and alcohol use disorder comorbidity
HC Becker, MF Lopez, CE King, WC Griffin - Biological psychiatry, 2023 - Elsevier
Background There is high comorbidity of posttraumatic stress disorder (PTSD) and alcohol
use disorder with few effective treatment options. Animal models of PTSD have shown …
use disorder with few effective treatment options. Animal models of PTSD have shown …
Psychobiotic interventions attenuate chronic alcohol use-mediated exacerbation of posttraumatic stress disorder in rats: the role of gut-liver axis response
ET Akinluyi, EE Edem, KM Dakoru… - … of Complementary and …, 2023 - degruyter.com
Objectives The incidence of co-occurring alcohol-use disorder (AUD) and post-traumatic
stress disorder (PTSD) is high, and the presence of one disorder aggravates the severity of …
stress disorder (PTSD) is high, and the presence of one disorder aggravates the severity of …