Mesenchymal stem cell-derived extracellular vesicles: opportunities and challenges for clinical translation
M Maumus, P Rozier, J Boulestreau… - … in Bioengineering and …, 2020 - frontiersin.org
Extracellular vesicles (EVs), including exosomes and microvesicles, derived from
mesenchymal stem/stromal cells (MSCs) exert similar effects as their parental cells, and are …
mesenchymal stem/stromal cells (MSCs) exert similar effects as their parental cells, and are …
A systematic review of preclinical studies on the therapeutic potential of mesenchymal stromal cell-derived microvesicles
Background The therapeutic potential of mesenchymal stromal cells (MSCs) may be largely
mediated by paracrine factors contained in microvesicles (MV) released from intracellular …
mediated by paracrine factors contained in microvesicles (MV) released from intracellular …
Small extracellular vesicles containing miR-486-5p promote angiogenesis after myocardial infarction in mice and nonhuman primates
Q Li, Y Xu, K Lv, Y Wang, Z Zhong, C Xiao… - Science translational …, 2021 - science.org
Stem cell–derived small extracellular vesicles (sEVs) promote angiogenesis after
myocardial infarction (MI). However, the components of sEVs that contribute to these effects …
myocardial infarction (MI). However, the components of sEVs that contribute to these effects …
Human bone marrow-and adipose-mesenchymal stem cells secrete exosomes enriched in distinctive miRNA and tRNA species
SR Baglio, K Rooijers, D Koppers-Lalic… - Stem cell research & …, 2015 - Springer
Introduction Administration of mesenchymal stem cells (MSCs) represents a promising
treatment option for patients suffering from immunological and degenerative disorders …
treatment option for patients suffering from immunological and degenerative disorders …
MSC transplantation improves osteopenia via epigenetic regulation of notch signaling in lupus
S Liu, D Liu, C Chen, K Hamamura, A Moshaverinia… - Cell metabolism, 2015 - cell.com
Mesenchymal stem cell transplantation (MSCT) has been used to treat human diseases, but
the detailed mechanisms underlying its success are not fully understood. Here we show that …
the detailed mechanisms underlying its success are not fully understood. Here we show that …
[HTML][HTML] Mesenchymal stem cells for the management of inflammation in osteoarthritis: state of the art and perspectives
YM Pers, M Ruiz, D Noël, C Jorgensen - Osteoarthritis and cartilage, 2015 - Elsevier
Osteoarthritis (OA) is the most common form of degenerative arthritis, mainly characterized
by the degradation of articular cartilage and associated with subchondral bone lesions …
by the degradation of articular cartilage and associated with subchondral bone lesions …
Mesenchymal stromal cell therapy: progress in manufacturing and assessments of potency
Mesenchymal stromal cell (MSC) therapies have been pursued for a broad spectrum of
indications but mixed reports on clinical efficacy have given rise to some degree of …
indications but mixed reports on clinical efficacy have given rise to some degree of …
Therapeutic potential of multipotent mesenchymal stromal cells and their extracellular vesicles
N Heldring, I Mäger, MJA Wood, K Le Blanc… - Human gene …, 2015 - liebertpub.com
The therapeutic potential of mesenchymal stromal cells (MSCs) is evident by the number of
new and ongoing trials targeting an impressive variety of conditions. In bone and cartilage …
new and ongoing trials targeting an impressive variety of conditions. In bone and cartilage …
ADSC-derived exosomes attenuate myocardial infarction injury by promoting miR-205-mediated cardiac angiogenesis
T Wang, T Li, X Niu, L Hu, J Cheng, D Guo, H Ren… - Biology direct, 2023 - Springer
Background Acute myocardial infarction is a major health problem and is the leading cause
of death worldwide. Myocardial apoptosis induced by myocardial infarction injury is involved …
of death worldwide. Myocardial apoptosis induced by myocardial infarction injury is involved …
Potential effects of MSC-derived exosomes in neuroplasticity in Alzheimer's disease
EE Reza-Zaldivar, MA Hernández-Sapiéns… - Frontiers in cellular …, 2018 - frontiersin.org
Alzheimer's disease (AD) is the most common type of dementia affecting regions of the
central nervous system that exhibit synaptic plasticity and are involved in higher brain …
central nervous system that exhibit synaptic plasticity and are involved in higher brain …