COVID-19, cytokines, inflammation, and spices: How are they related?

AB Kunnumakkara, V Rana, D Parama, K Banik… - Life sciences, 2021 - Elsevier
Background Cytokine storm is the exaggerated immune response often observed in viral
infections. It is also intimately linked with the progression of COVID-19 disease as well as …

Diosgenin, a steroidal saponin, and its analogs: Effective therapies against different chronic diseases

D Parama, M Boruah, K Yachna, V Rana, K Banik… - Life sciences, 2020 - Elsevier
Background Chronic diseases are a major cause of mortality worldwide, and despite the
recent development in treatment modalities, synthetic drugs have continued to show toxic …

Dual synergistic inhibition of COX and LOX by potential chemicals from Indian daily spices investigated through detailed computational studies

M Rudrapal, WA Eltayeb, G Rakshit, AA El-Arabey… - Scientific Reports, 2023 - nature.com
Abstract Cyclooxygenase (COX) and Lipoxygenase (LOX) are essential enzymes for
arachidonic acid (AA) to eicosanoids conversion. These AA-derived eicosanoids are …

Rationalizing the therapeutic potential of apigenin against cancer

SA Ahmed, D Parama, E Daimari, S Girisa, K Banik… - Life sciences, 2021 - Elsevier
Background Despite the remarkable advances made in the diagnosis and treatment of
cancer during the past couple of decades, it remains the second largest cause of mortality in …

Xanthohumol from Hop: Hope for cancer prevention and treatment

S Girisa, Q Saikia, D Bordoloi, K Banik, J Monisha… - IUBMB …, 2021 - Wiley Online Library
Cancer is a major public health concern due to high mortality and poor quality of life of
patients. Despite the availability of advanced therapeutic interventions, most treatment …

Mycotoxins in spices and herbs–An update

B Kabak, ADW Dobson - Critical reviews in food science and …, 2017 - Taylor & Francis
Spices and herbs have been used since ancient times as flavor and aroma enhancers,
colorants, preservatives, and traditional medicines. There are more than 30 spices and …

Neuroprotection by spice-derived nutraceuticals: you are what you eat!

R Kannappan, SC Gupta, JH Kim, S Reuter… - Molecular …, 2011 - Springer
Numerous lines of evidence indicate that chronic inflammation plays a major role in the
development of various neurodegenerative diseases, including Alzheimer's disease …

Natural compounds targeting nuclear receptors for effective cancer therapy

M Hegde, S Girisa, N Naliyadhara, A Kumar… - Cancer and Metastasis …, 2023 - Springer
Human nuclear receptors (NRs) are a family of forty-eight transcription factors that modulate
gene expression both spatially and temporally. Numerous biochemical, physiological, and …

Blood Pressure Lowering Effect of Nigella sativa L. Seed Oil in Healthy Volunteers: A Randomized, Double‐Blind, Placebo‐controlled Clinical Trial

H Fallah Huseini, M Amini, R Mohtashami… - Phytotherapy …, 2013 - Wiley Online Library
Nigella sativa L. seeds (N. sativa) have been used as a traditional remedy for a wide range
of diseases including hypertension. The present study was performed to explore the effects …

Capsicum annuum L. and its bioactive constituents: A critical review of a traditional culinary spice in terms of its modern pharmacological potentials with toxicological …

SK Mandal, SK Rath, R Logesh, SK Mishra… - Phytotherapy …, 2023 - Wiley Online Library
Capsicum annuum L., commonly known as chili pepper, is used as an important spice
globally and as a crude drug in many traditional medicine systems. The fruits of C. annuum …