A large proportion of protein–protein interactions (PPIs) occur between a short peptide and a
globular protein domain; the peptides involved in surface interactions play important roles …

Protein-protein interaction (PPI) is a hot topic in clinical research as protein networking has a
major impact in human disease. Such PPIs are potential drugs targets, leading to the need …

Protein–protein interactions (PPIs) are implicated in the majority of cellular processes by
enabling and regulating the function of individual proteins. Thus, PPIs represent high-value …

Blocking the association between the severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) spike protein receptor-binding domain (RBD) and the human angiotensin …

The central dogma of modern biology underscores the pivotal roles proteins play in diverse
biological processes, the study of which necessitates advanced methods to produce …

Highlights•One of the most widely adopted strategies for α-helix stabilisation is peptide
stapling.•Stapled peptides are highly promising therapeutic agents.•General design …

Interactions between the pro-survival and pro-apoptotic members of the Bcl-2 family of
proteins dictate whether a cell lives or dies. Much of our knowledge of the molecular details …

The development of constrained peptides for inhibition of protein–protein interactions is an
emerging strategy in chemical biology and drug discovery. This manuscript introduces a …

Despite its high potential, PD-L1 expressed by tumors has not been successfully utilized as
a biomarker for estimating treatment responses to immunotherapy. Circulating tumor cells …

Therapeutic peptides have revolutionized treatment for a number of human diseases. In
particular, the past two decades have witnessed rapid progress of stapled helical peptides in …