Immune checkpoint therapy has achieved significant efficacy by blocking inhibitory
pathways to release the function of T lymphocytes. In the clinic, anti-programmed cell death …

Epithelial–mesenchymal transition (EMT) is a program wherein epithelial cells lose their
junctions and polarity while acquiring mesenchymal properties and invasive ability …

Background Pancreatic cancer is characterized by extensive metastasis. Epithelial-
mesenchymal transition (EMT) plasticity plays a critical role in tumor progression and …

Background & Aims Pancreatic cancer has the highest prevalence of cancer-associated
cachexia among all cancers. ZIP4 promotes pancreatic cancer progression by regulating …

Zinc is an essential trace element that plays important roles in the regulation of various
physiological responses in the body. Zinc deficiency is known to cause various health …

Neutrophil extracellular DNA traps (NETs) are newly discovered forms of activated
neutrophils. Increasing researches have shown that NETs play important roles in cancer …

Zinc is an essential element and serves as a structural or catalytic component in many
proteins. Two families of transporters are involved in maintaining cellular zinc homeostasis …

Claudins are a tetraspan membrane protein multigene family that plays a structural and
functional role in constructing tight junctions. Claudins perform crucial roles in maintaining …

Background & Aims Cachexia, which includes muscle wasting, is a frequent complication of
pancreatic cancer. There are no therapies that reduce cachexia and increase patient …

Background & Aims Pancreatic tumors undergo rapid growth and progression, become
resistant to chemotherapy, and recur after surgery. We studied the functions of the solute …