Impacts of bioinformatics to medicinal chemistry
KC Chou - Medicinal chemistry, 2015 - ingentaconnect.com
Facing the explosive growth of biological sequence data, such as those of protein/peptide
and DNA/RNA, generated in the post-genomic age, many bioinformatical and mathematical …
and DNA/RNA, generated in the post-genomic age, many bioinformatical and mathematical …
An unprecedented revolution in medicinal chemistry driven by the progress of biological science
KC Chou - Current topics in medicinal chemistry, 2017 - ingentaconnect.com
The eternal or ultimate goal of medicinal chemistry is to find most effective ways to treat
various diseases and extend human beings' life as long as possible. Human being is a …
various diseases and extend human beings' life as long as possible. Human being is a …
[HTML][HTML] iDNA6mA-PseKNC: Identifying DNA N6-methyladenosine sites by incorporating nucleotide physicochemical properties into PseKNC
Abstract N 6-methyladenine (6mA) is one kind of post-replication modification (PTM or
PTRM) occurring in a wide range of DNA sequences. Accurate identification of its sites will …
PTRM) occurring in a wide range of DNA sequences. Accurate identification of its sites will …
iPromoter-2L: a two-layer predictor for identifying promoters and their types by multi-window-based PseKNC
B Liu, F Yang, DS Huang, KC Chou - Bioinformatics, 2018 - academic.oup.com
Motivation Being responsible for initiating transaction of a particular gene in genome,
promoter is a short region of DNA. Promoters have various types with different functions …
promoter is a short region of DNA. Promoters have various types with different functions …
[HTML][HTML] iACP: a sequence-based tool for identifying anticancer peptides
Cancer remains a major killer worldwide. Traditional methods of cancer treatment are
expensive and have some deleterious side effects on normal cells. Fortunately, the …
expensive and have some deleterious side effects on normal cells. Fortunately, the …
iEnhancer-2L: a two-layer predictor for identifying enhancers and their strength by pseudo k-tuple nucleotide composition
Motivation: Enhancers are of short regulatory DNA elements. They can be bound with
proteins (activators) to activate transcription of a gene, and hence play a critical role in …
proteins (activators) to activate transcription of a gene, and hence play a critical role in …
iRNA-Methyl: Identifying N6-methyladenosine sites using pseudo nucleotide composition
Occurring at adenine (A) with the consensus motif GAC, N 6-methyladenosine (m 6 A) is one
of the most abundant modifications in RNA, which plays very important roles in many …
of the most abundant modifications in RNA, which plays very important roles in many …
iRNA-PseColl: identifying the occurrence sites of different RNA modifications by incorporating collective effects of nucleotides into PseKNC
There are many different types of RNA modifications, which are essential for numerous
biological processes. Knowledge about the occurrence sites of RNA modifications in its …
biological processes. Knowledge about the occurrence sites of RNA modifications in its …
PseKNC: a flexible web server for generating pseudo K-tuple nucleotide composition
The pseudo oligonucleotide composition, or pseudo K-tuple nucleotide composition
(PseKNC), can be used to represent a DNA or RNA sequence with a discrete model or …
(PseKNC), can be used to represent a DNA or RNA sequence with a discrete model or …
iProt-Sub: a comprehensive package for accurately mapping and predicting protease-specific substrates and cleavage sites
Regulation of proteolysis plays a critical role in a myriad of important cellular processes. The
key to better understanding the mechanisms that control this process is to identify the …
key to better understanding the mechanisms that control this process is to identify the …