Technological advances and clinical research over the past few decades have given
radiation oncologists the capability to personalize treatments for accurate delivery of …

Tumour hypoxia is increasingly recognized as a major deleterious factor in cancer therapies,
as it compromises treatment and drives malignant progression. This review seeks to clarify …

Data from 125 studies describing the pretreatment oxygenation status as measured in the
clinical setting using the computerized Eppendorf pO2 histography system have been …

From background physics and biological models to the latest imaging and treatment
modalities, the Handbook of Radiotherapy Physics: Theory and Practice covers all …

Purpose: The Cancer Imaging Program of the National Cancer Institute convened a
workshop to assess the current status of hypoxia imaging, to assess what is known about the …

Dose painting is the prescription of a nonuniform radiation dose distribution to the target
volume based on functional or molecular images shown to indicate the local risk of relapse …

Solid tumors consist of cancer cells and stromal cells, including resident and transiting
immune cells—all ensconced in an extracellular matrix (ECM)—nourished by blood vessels …

Recent preclinical studies have suggested that radiotherapy in combination with
antiangiogenic/vasculature targeting agents enhances the therapeutic ratio of ionizing …

Background Expression of intrinsic markers of tumour hypoxia and angiogenesis are
important predictors of radiotherapeutic, and possibly surgical, outcome in several cancers …

Hypoxia is a physiologically important endoplasmic reticulum (ER) stress that is present in
all solid tumors. Numerous clinical studies have shown that tumor hypoxia predicts for …