▪ Abstract The neurons of the cochlear ganglion transmit acoustic information between the
inner ear and the brain. These placodally derived neurons must produce a topographically …

Endometrial cancer is the most common gynaecological cancer, and is associated with
endometrial hyperplasia, unopposed oestrogen exposure and adjuvant therapy for breast …

Patterning the vertebrate ear requires the coordinated expression of genes that are involved
in morphogenesis, neurogenesis, and hair cell formation. The zinc finger gene GATA‐3 is …

Generating the diversity of cell types in the inner ear may require an interplay between
regional compartmentalization and local cellular interactions. Recent evidence has come …

Auditory hair cells contain mechanotransduction channels that rapidly open in response to
sound-induced vibrations. We report here that auditory hair cells contain two molecularly …

The highly orchestrated processes that generate the vertebrate inner ear from the otic
placode provide an excellent and circumscribed testing ground for fundamental cellular and …

During development, the vertebrate inner ear arises from the otic placode, a thickened
portion of the ectoderm next to the hindbrain. Here, the first detailed fate maps of this region …

Mice that lack the winged helix/forkhead gene Foxi1 (also known as Fkh10) are deaf and
display shaker/waltzer behavior, an indication of disturbed balance. While Foxi1 is …

The transcription factors GATA3 and Pax2 are expressed throughout development of the
mouse inner ear. We have used antibodies to study their temporal and spatial expression …

Cranial sensory placodes are focused areas of the head ectoderm of vertebrates that
contribute to the development of the cranial sense organs and their associated ganglia …