The study of protein subcellular distribution, their assembly into complexes and the set of
proteins with which they interact with is essential to our understanding of fundamental …

Enzyme-and catalyst-generated reactive species have been leveraged in the past decade to
covalently label biomolecules within a short range of a defined site or space inside cells or …

Proteome-wide profiling of protein phosphorylation has been widely used to reveal the
underlying mechanism of diverse cellular signaling events. Yet, characterizing subcellular …

FKBP51 and FKBP52 are two iconic members of the family of peptidyl-prolyl-(cis/trans)-
isomerases (EC: 5.2. 1.8), which comprises proteins that catalyze the cis/trans isomerization …

We have previously shown that the holocarboxylase synthetase (HLCS) is overexpressed in
breast cancer tissue of patients, and silencing of its expression in triple-negative cancer cell …

Biotin is an essential cofactor for multiple metabolic reactions catalyzed by carboxylases.
Biotin is covalently linked to apoproteins by holocarboxylase synthetase (HCS). Accordingly …

Post-translational modifications of cellular substrates by members of the ubiquitin (Ub) and
ubiquitin-like (UbL) family are crucial for regulating protein homeostasis in organisms. The …

Background/Aim: Holocarboxylase synthetase (HLCS) catalyzes the specific attachment of
biotin onto biotin-dependent carboxylases (BDCs) which play important roles in intermediary …

Biotin (Vitamin B7) is a critical enzyme co-factor in metabolic pathways important for
bacterial survival. Biotin is obtained either from the environment or by de novo synthesis …

Витаминами являются низкомолекулярные вещества, получаемые главным образом с
пищей и составляющие эссенциальную часть рациона питания человека. После …