Neurodegenerative diseases pose a substantial socioeconomic burden on society.
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …

Melatonin is a neurohormone secreted from the pineal gland and has a wide‐ranging
regulatory and neuroprotective role. It has been reported that melatonin level is disturbed in …

Acetylcholinesterase (AChE) plays an important role in the pathogenesis of
neurodegenerative diseases by influencing the inflammatory response, apoptosis, oxidative …

Both Alzheimer's disease (AD) and Type 2 diabetes mellitus (T2DM) share the presence of
systemic and neuro-inflammation, enhanced production and accumulation of β-amyloid …

The discovery of the first neurotransmitter—acetylcholine—was soon followed by the
discovery of its hydrolysing enzyme, acetylcholinesterase. The role of acetylcholinesterase …

Alzheimer's disease (AD) is a generalized term used for the loss in memory and other
intellectual abilities on levels serious enough to interfere with daily life. It accounts for 60 …

Abstract The cholinesterase inhibitors (ChE-Is) attenuate the cholinergic deficit underlying
the cognitive and neuropsychiatric dysfunctions in patients with AD. Inhibition of brain …

Life's Journey If life is indeed a journey, then poetry must be the map that reveals all its
topographic possibilities… while science is the compass that keeps us from getting lost.—RT …

Huperzine A (HupA), an alkaloid found in the club moss Huperzia serrata, has been used for
centuries in Chinese folk medicine to treat dementia. The effects of this alkaloid have been …

The aggregation of β-amyloid (1–40)(Aβ) induced by human recombinant
acetylcholinesterase (HuAChE) was studied by means of circular dichroism (CD) and by …