Cognition in multiple sclerosis: State of the field and priorities for the future

JF Sumowski, R Benedict, C Enzinger, M Filippi… - Neurology, 2018 - AAN Enterprises
Cognitive decline is recognized as a prevalent and debilitating symptom of multiple sclerosis
(MS), especially deficits in episodic memory and processing speed. The field aims to (1) …

Epidemiology and treatment of multiple sclerosis in elderly populations

CB Vaughn, D Jakimovski, KS Kavak… - Nature Reviews …, 2019 - nature.com
The prevalence of multiple sclerosis (MS) and the age of affected patients are increasing
owing to increased longevity of the general population and the availability of effective …

Mindboggling morphometry of human brains

A Klein, SS Ghosh, FS Bao, J Giard… - PLoS computational …, 2017 - journals.plos.org
Mindboggle (http://mindboggle. info) is an open source brain morphometry platform that
takes in preprocessed T1-weighted MRI data and outputs volume, surface, and tabular data …

Deep gray matter volume loss drives disability worsening in multiple sclerosis

A Eshaghi, F Prados, WJ Brownlee… - Annals of …, 2018 - Wiley Online Library
Objective Gray matter (GM) atrophy occurs in all multiple sclerosis (MS) phenotypes. We
investigated whether there is a spatiotemporal pattern of GM atrophy that is associated with …

Translational value of choroid plexus imaging for tracking neuroinflammation in mice and humans

V Fleischer, G Gonzalez-Escamilla… - Proceedings of the …, 2021 - National Acad Sciences
Neuroinflammation is a pathophysiological hallmark of multiple sclerosis and has a close
mechanistic link to neurodegeneration. Although this link is potentially targetable, robust …

Progression of regional grey matter atrophy in multiple sclerosis

A Eshaghi, RV Marinescu, AL Young, NC Firth… - Brain, 2018 - academic.oup.com
Abstract See Stankoff and Louapre (doi: 10.1093/brain/awy114) for a scientific commentary
on this article. Grey matter atrophy is present from the earliest stages of multiple sclerosis …

Identifying the distinct cognitive phenotypes in multiple sclerosis

E De Meo, E Portaccio, A Giorgio, L Ruano… - JAMA …, 2021 - jamanetwork.com
Importance Cognitive impairment is a common and disabling feature of multiple sclerosis
(MS), but a precise characterization of cognitive phenotypes in patients with MS is lacking …

Predicting cognitive decline in multiple sclerosis: a 5-year follow-up study

AJC Eijlers, Q van Geest, I Dekker, MD Steenwijk… - Brain, 2018 - academic.oup.com
Cognitive decline is common in multiple sclerosis and strongly affects overall quality of life.
Despite the identification of cross-sectional MRI correlates of cognitive impairment …

Multiple sclerosis and cognition: synaptic failure and network dysfunction

M Di Filippo, E Portaccio, A Mancini… - Nature Reviews …, 2018 - nature.com
Cognitive impairment is increasingly recognized to be a core feature of multiple sclerosis
(MS), with important implications for the everyday life of individuals with MS and for disease …

Comprehensive approach to management of multiple sclerosis: addressing invisible symptoms—a narrative review

L Lakin, BE Davis, CC Binns, KM Currie… - Neurology and therapy, 2021 - Springer
Multiple sclerosis (MS) is a chronic autoimmune inflammatory disease of the central nervous
system, leading to neurodegeneration and manifesting as a variety of symptoms. These can …