[HTML][HTML] Evolution of chemistry and selection technology for DNA-encoded library
P Ma, S Zhang, Q Huang, Y Gu, Z Zhou, W Hou… - … Pharmaceutica Sinica B, 2024 - Elsevier
DNA-encoded chemical library (DEL) links the power of amplifiable genetics and the non-
self-replicating chemical phenotypes, generating a diverse chemical world. In analogy with …
self-replicating chemical phenotypes, generating a diverse chemical world. In analogy with …
Design and Preclinical Evaluation of a Novel Prostate-Specific Membrane Antigen Radioligand Modified with a Transthyretin Binder
Simple Summary Prostate-specific membrane antigen (PSMA)-targeting radioligands have
been used clinically to treat metastatic prostate cancer. To deliver a sufficient radiation dose …
been used clinically to treat metastatic prostate cancer. To deliver a sufficient radiation dose …
KinDEL: DNA-Encoded Library Dataset for Kinase Inhibitors
DNA-Encoded Libraries (DEL) are combinatorial small molecule libraries that offer an
efficient way to characterize diverse chemical spaces. Selection experiments using DELs …
efficient way to characterize diverse chemical spaces. Selection experiments using DELs …
DEL+ ML paradigm for actionable hit discovery–a cross DEL and cross ML model assessment.
DNA-Encoded Library (DEL) technology allows the screening of millions, or even billions, of
encoded compounds in a pooled fashion which is faster and cheaper than traditional …
encoded compounds in a pooled fashion which is faster and cheaper than traditional …
A resource to enable chemical biology and drug discovery of WDR Proteins
CH Arrowsmith, S Ackloo, F Li, M Szewczyk, A Seitova… - bioRxiv, 2024 - biorxiv.org
Protein class-focused drug discovery has a long and successful history in pharmaceutical
research, yet most members of druggable protein families remain unliganded, often for …
research, yet most members of druggable protein families remain unliganded, often for …