Pharmacogenetics: implications of race and ethnicity on defining genetic profiles for personalized medicine

VE Ortega, DA Meyers - Journal of allergy and clinical immunology, 2014 - Elsevier
Pharmacogenetics is being used to develop personalized therapies specific to subjects from
different ethnic or racial groups. To date, pharmacogenetic studies have been primarily …

Asthma in Hispanics. An 8-year update

FJ Rosser, E Forno, PJ Cooper… - American journal of …, 2014 - atsjournals.org
This review provides an update on asthma in Hispanics, a diverse group tracing their
ancestry to countries previously under Spanish rule. A marked variability in the prevalence …

Genome-wide patterns of population structure and admixture among Hispanic/Latino populations

K Bryc, C Velez, T Karafet… - Proceedings of the …, 2010 - National Acad Sciences
Hispanic/Latino populations possess a complex genetic structure that reflects recent
admixture among and potentially ancient substructure within Native American, European …

Assessing individual interethnic admixture and population substructure using a 48–insertion‐deletion (INSEL) ancestry‐informative marker (AIM) panel

NPC Santos, EM Ribeiro‐Rodrigues… - Human …, 2010 - Wiley Online Library
Estimating the proportions of different ancestries in admixed populations is very important in
population genetics studies, and it is particularly important for detecting population …

The Biologistical Construction of Race: Admixture'Technology and the New Genetic Medicine

D Fullwiley - Social studies of science, 2008 - journals.sagepub.com
This paper presents an ethnographic case study of the use of race in two interconnected
laboratories of medical genetics. Specifically, it examines how researchers committed to …

Genetic ancestry influences asthma susceptibility and lung function among Latinos

M Pino-Yanes, N Thakur, CR Gignoux… - Journal of Allergy and …, 2015 - Elsevier
Background Childhood asthma prevalence and morbidity varies among Latinos in the
United States, with Puerto Ricans having the highest and Mexicans the lowest. Objective To …

History shaped the geographic distribution of genomic admixture on the island of Puerto Rico

M Via, CR Gignoux, LA Roth, L Fejerman, J Galanter… - PloS one, 2011 - journals.plos.org
Contemporary genetic variation among Latin Americans human groups reflects population
migrations shaped by complex historical, social and economic factors. Consequently …

Comparing genetic ancestry and self-described race in African Americans born in the United States and in Africa

R Yaeger, A Avila-Bront, K Abdul, PC Nolan… - … Biomarkers & Prevention, 2008 - AACR
Genetic association studies can be used to identify factors that may contribute to disparities
in disease evident across different racial and ethnic populations. However, such studies may …

Disparities in mortality of hispanic patients with cystic fibrosis in the United States. A national and regional cohort study

J Rho, C Ahn, A Gao, GS Sawicki, A Keller… - American journal of …, 2018 - atsjournals.org
Rationale: Patients of Hispanic origin with cystic fibrosis (CF) are the largest growing
minority, representing 8.5% of patients with CF in the United States. No national survival …

Softwares and methods for estimating genetic ancestry in human populations

Y Liu, T Nyunoya, S Leng, SA Belinsky, Y Tesfaigzi… - Human genomics, 2013 - Springer
The estimation of genetic ancestry in human populations has important applications in
medical genetic studies. Genetic ancestry is used to control for population stratification in …