Endometriosis, a benign gynecologic and chronic inflammatory disease, is defined by the
presence of endometrial tissue outside the uterus characterized mainly by pelvic pain and …

Cancers of the reproductive organs have a strong association with mitochondrial defects,
and a deeper understanding of the role of this organelle in preneoplastic–neoplastic …

Aim: Accurate noninvasive diagnostic aids for endometriosis are needed. We evaluated
mitochondrial DNA deletions as potential biomarkers for endometriosis. Methods: The …

There is an increasing understanding of the molecular and cytogenetic background of
various tumors that helps us better conceptualize the pathogenesis of specific diseases …

Type I endometrial cancer (EC) is the most common form of EC, displaying less aggressive
behavior than type II. The development of type I endometrial cancer is considered a …

Endometrial carcinoma (EC) is a solid neoplasia for which a role for mitochondria in cancer
progression is currently emerging and yet represents a diagnostic and prognostic challenge …

The transcription factor hypoxia inducible factor-1 (HIF-1) is one of the main factors in the
cell's response to a lack of oxygen. Hypoxia is a typical feature of a growing cancerous …

Endometrial carcinoma is the most commonly diagnosed gynaecological cancer in
developed countries. Although the molecular genetics of this disease has been in the focus …

Exciting new studies are increasingly strengthening the link between mitochondrial
mutagenesis and tumor progression. Here we provide a comprehensive review and meta …

mtDNA4977, the most common deletion of the mitochondrial DNA, has been detected in
different types of human neoplasia. The aim of the current study was to determine the …