Biological aging involves an interplay of conserved and targetable molecular mechanisms,
summarized as the hallmarks of aging. Metformin, a biguanide that combats age-related …

The numerous beneficial health outcomes associated with the use of metformin to treat
patients with type 2 diabetes (T2DM), together with data from pre-clinical studies in animals …

Metformin, the most prescribed antidiabetic medicine, has shown other benefits such as anti-
ageing and anticancer effects,,–. For clinical doses of metformin, AMP-activated protein …

Metformin is a widely-used drug that results in clear benefits in relation to glucose
metabolism and diabetes-related complications. The mechanisms underlying these benefits …

BACKGROUND As the world population ages, chronic diseases such as diabetes,
cardiovascular disease, cancer, and neurodegeneration become ever more prevalent …

Metformin is a well-known anti-diabetic drug that has been repurposed for several emerging
applications, including as an anti-cancer agent. It boasts the distinct advantages of an …

During starvation the transcriptional activation of catabolic processes is induced by the
nuclear translocation and consequent activation of transcription factor EB (TFEB), a master …

Abstract Purpose of Review Metformin has multiple benefits for health beyond its anti-
hyperglycemic properties. The purpose of this manuscript is to review the mechanisms that …

Metformin is a drug from the biguanide family that is used for decades as the first-line
therapeutic choice for the treatment of type 2 diabetes. Despite its worldwide …

Metformin is the most commonly prescribed drug for type 2 diabetes mellitus. In recent years,
in addition to glucose lowering, several studies have presented evidence suggesting some …