Structure-activity relationship (SAR) study and design strategies of nitrogen-containing heterocyclic moieties for their anticancer activities
The present review article offers a detailed account of the design strategies employed for the
synthesis of nitrogen-containing anticancer agents. The results of different studies describe …
synthesis of nitrogen-containing anticancer agents. The results of different studies describe …
Recent advances (2015–2016) in anticancer hybrids
In spite of the development of a large number of novel anticancer drugs over the years,
Cancer remains as a prominent cause of death, worldwide. Numerous drugs that are …
Cancer remains as a prominent cause of death, worldwide. Numerous drugs that are …
Rational approaches, design strategies, structure activity relationship and mechanistic insights for anticancer hybrids
A Hybrid drug which comprises the incorporation of two drug pharmacophores in one single
molecule are basically designed to interact with multiple targets or to amplify its effect …
molecule are basically designed to interact with multiple targets or to amplify its effect …
[HTML][HTML] A comprehensive review on pyrazoline based heterocyclic hybrids as potent anticancer agents
Cancer is one of the leading causes of death globally, around 10 million deaths are reported
every year due to cancer. Some clinically approved anticancer drugs play a riveting role in …
every year due to cancer. Some clinically approved anticancer drugs play a riveting role in …
Advances in the development of hybrid anticancer drugs
Introduction: Hybrid anticancer drugs are of great therapeutic interests as they can
potentially overcome most of the pharmacokinetic drawbacks encountered when using …
potentially overcome most of the pharmacokinetic drawbacks encountered when using …
A mini review on isatin, an anticancer scaffold with potential activities against neglected tropical diseases (NTDs)
Isatin, chemically an indole-1 H-2, 3-dione, is recognised as one of the most attractive
therapeutic fragments in drug design and development. The template has turned out to be …
therapeutic fragments in drug design and development. The template has turned out to be …
Recent advances in isatin hybrids as potential anticancer agents
Z Ding, M Zhou, C Zeng - Archiv der Pharmazie, 2020 - Wiley Online Library
The isatin framework is a useful template for the development of novel anticancer agents.
This is exemplified by the fact that several isatin‐based anticancer agents, such as …
This is exemplified by the fact that several isatin‐based anticancer agents, such as …
Triazole tethered isatin-coumarin based molecular hybrids as novel antitubulin agents: Design, synthesis, biological investigation and docking studies
In an attempt to develop potent anti-tubulin agents against most dreadful disease cancer, a
library of 28 novel triazole tethered isatin-coumarin hybrids were synthesized by click …
library of 28 novel triazole tethered isatin-coumarin hybrids were synthesized by click …
Azide-alkyne cycloaddition en route to 1H-1, 2, 3-triazole-tethered 7-chloroquinoline-isatin chimeras: Synthesis and antimalarial evaluation
We describe the synthesis and antimalarial activities of 1H-1, 2, 3-triazole tethered 7-
chloroquinoline-isatin hybrids. Activity against cultured parasites was dependent on the C-5 …
chloroquinoline-isatin hybrids. Activity against cultured parasites was dependent on the C-5 …
Isatin dimers and their biological activities
YZ Zhang, HZ Du, HL Liu, QS He, Z Xu - Archiv der Pharmazie, 2020 - Wiley Online Library
Dimerization is a promising strategy to develop novel drug candidates that could extend the
biological spectrum, enhance the activity, overcome drug resistance, as well as improve …
biological spectrum, enhance the activity, overcome drug resistance, as well as improve …