Natural populations harbor considerable genetic variation for lifespan. While evolutionary
theory provides general explanations for the existence of this variation, our knowledge of the …

ABSTRACT AGAP1 is an Arf1 GTPase-activating protein that regulates endolysosomal
trafficking. Damaging variants have been linked to cerebral palsy and autism. We report …

Phosphoinositide 3-kinase enhancer (PIKE) belongs to a family of GTP-binding proteins,
including three isoforms, PIKE-S, PIKE-L and PIKE-A. PIKE-S and PIKE-L interact with PI3K …

Synthesis of ecdysone, the key hormone that signals the termination of larval growth and the
initiation of metamorphosis in insects, is carried out in the prothoracic gland by an array of …

Cereblon (CRBN) is a substrate receptor of the E3 ubiquitin ligase complex that is highly
conserved in animals and plants. CRBN proteins have been implicated in various biological …

Body size is one of the features that distinguish one species from another in the biological
world. Animals have developed mechanisms to control their body size during normal …

Phosphatidylserine (PS) 은 인지질 이중층의 주요 구성 성분 중 하나이다. PS 는 소포체의
미토콘드리아 관련 막에 있는 Phosphatidyl-serine Synthase 라는 효소에 의해 합성된다. 이 …

Spatial organization of signalling network components is essential to ensure appropriate
activation of signalling pathways. Polarized sorting of Epidermal Growth Factor Receptor …

La mosca de la fruta es un organismo importante en la genética y la biología del desarrollo,
presenta un ciclo de vida corto el cual facilita diversas pruebas y ensayos con diferentes …

Abstract Development time differences can have an impact on the organism and its history.
In Drosophila there is an association between development time, lifespan and adult size …