The use of animal models in drug discovery studies presents issues with feasibility and
ethical concerns. To address these limitations, in vitro tissue models have been developed …

Abstract 2D cell culture and preclinical animal models have traditionally been implemented
for investigating the underlying cellular mechanisms of human disease progression …

Written by more than 400 subject experts representing diverse academic and applied
domains, this multidisciplinary resource surveys the vanguard of biomaterials and …

Controlled assembly of collagen molecules in vitro remains a major challenge for fabricating
the next generation of engineered tissues. Here we present a novel electrochemical …

Three dimensional gels of aligned collagen fibers were patterned in vitro using microfluidic
channels. Collagen fiber orientation plays an important role in cell signaling for many tissues …

Nanostructured scaffolds recently showed great promise in tissue engineering:
nanomaterials can be tailored at the molecular level and scaffold morphology may more …

Collagen fibers are usually arranged with a complex structure in the body, and their
arrangement is considered to play an important role in stimulating cell adhesion, migration …

Cardiomyocytes actively proliferate during embryogenesis and withdraw from the cell cycle
during neonatal stages. FOXO (Forkhead O) transcription factors are a direct target of …

Wnt signaling mediated by β-catenin has been implicated in early endocardial cushion
development, but its roles in later stages of heart valve maturation and homeostasis have …

Gold-coated collagen nanofibers (GCNFs) were produced by a single-step reduction
process and used for the growth and differentiation of human adult stem cells. The …