Arthropod venom Hyaluronidases: biochemical properties and potential applications in medicine and biotechnology

KCF Bordon, GA Wiezel, FG Amorim… - Journal of venomous …, 2015 - SciELO Brasil
Hyaluronidases are enzymes that mainly degrade hyaluronan, the major glycosaminoglycan
of the interstitial matrix. They are involved in several pathological and physiological activities …

Insect gut structure, function, development and target of biological toxins

PJ Linser, RR Dinglasan - Advances in insect physiology, 2014 - Elsevier
Insects as vectors of disease to humans and domesticated animals and as direct agricultural
pests are a source of tremendous economic and health-related challenge. The eating habits …

Tissue- and time-dependent transcription in Ixodes ricinus salivary glands and midguts when blood feeding on the vertebrate host

M Kotsyfakis, A Schwarz, J Erhart, JMC Ribeiro - Scientific reports, 2015 - nature.com
Ixodes ricinus is a tick that transmits the pathogens of Lyme and several arboviral diseases.
Pathogens invade the tick midgut, disseminate through the hemolymph and are transmitted …

Aedes aegypti sialokinin facilitates mosquito blood feeding and modulates host immunity and vascular biology

I Martin-Martin, PCV Leon, L Amo, G Shrivastava… - Cell reports, 2022 - cell.com
Saliva from mosquitoes contains vasodilators that antagonize vasoconstrictors produced at
the bite site. Sialokinin is a vasodilator present in the saliva of Aedes aegypti. Here, we …

A Deep Insight into the Sialome of Male and Female Aedes aegypti Mosquitoes

JMC Ribeiro, I Martin-Martin, B Arca, E Calvo - PloS one, 2016 - journals.plos.org
Only adult female mosquitoes feed on blood, while both genders take sugar meals.
Accordingly, several compounds associated with blood feeding (ie vasodilators, anti-clotting …

A systems level analysis reveals transcriptomic and proteomic complexity in Ixodes ricinus midgut and salivary glands during early attachment and feeding

A Schwarz, S Tenzer, M Hackenberg, J Erhart… - Molecular & Cellular …, 2014 - ASBMB
Although pathogens are usually transmitted within the first 24–48 h of attachment of the
castor bean tick Ixodes ricinus, little is known about the tick's biological responses at these …

A Polychaete's Powerful Punch: Venom Gland Transcriptomics of Glycera Reveals a Complex Cocktail of Toxin Homologs

BM von Reumont, LI Campbell, S Richter… - Genome Biology and …, 2014 - academic.oup.com
Glycerids are marine annelids commonly known as bloodworms. Bloodworms have an
eversible proboscis adorned with jaws connected to venom glands. Bloodworms prey on …

Draft genome sequences of Hirudo medicinalis and salivary transcriptome of three closely related medicinal leeches

VV Babenko, OV Podgorny, VA Manuvera… - BMC genomics, 2020 - Springer
Background Salivary cell secretion (SCS) plays a critical role in blood feeding by medicinal
leeches, making them of use for certain medical purposes even today. Results We …

De novo assembly and annotation of the salivary gland transcriptome of Rhipicephalus appendiculatus male and female ticks during blood feeding

MH De Castro, D de Klerk, R Pienaar, AA Latif… - Ticks and Tick-Borne …, 2016 - Elsevier
Tick secretory proteins modulate haemostasis, inflammation and immune responses of the
host and are attractive recombinant anti-tick vaccine candidates. Yet, many of the proteins …

Transcriptional profiling and physiological roles of Aedes aegypti spermathecal-related genes

TV Pascini, M Ramalho-Ortigão, JM Ribeiro… - BMC genomics, 2020 - Springer
Background Successful mating of female mosquitoes typically occurs once, with the male
sperm being stored in the female spermatheca for every subsequent oviposition event. The …