Page 1 2021 ANTIBACTERIAL AGENTS IN CLINICAL AND PRECLINICAL DEVELOPMENT:
an overview and analysis World Health Organization Page 2 A PRE Page 3 2021 …

Macrolide antibiotics inhibit protein synthesis by targeting the bacterial ribosome. They bind
at the nascent peptide exit tunnel and partially occlude it. Thus, macrolides have been …

Mycobacterium tuberculosis (Mtb) infection is notoriously difficult to treat. Treatment efficacy
is limited by Mtb's intrinsic drug resistance, as well as its ability to evolve acquired resistance …

Bacterial persister cells are phenotypic variants that exhibit a transient non-growing state
and antibiotic tolerance. Here, we provide in vitro evidence of Staphylococcus aureus …

The quality of diffraction data obtained using silver and molybdenum microsources has been
compared for six model compounds with a wide range of absorption factors. The …

Macrolides represent a large family of protein synthesis inhibitors of great clinical interest
due to their applicability to human medicine. Macrolides are composed of a macrocyclic …

Ribosome profiling, which involves the deep sequencing of ribosome-protected mRNA
fragments, is a powerful tool for globally monitoring translation in vivo. The method has …

The translation of messenger RNA (mRNA) into protein and the folding of the resulting
protein into an active form are prerequisites for virtually every cellular process and represent …

Ribosome rescue pathways recycle stalled ribosomes and target problematic mRNAs and
aborted proteins for degradation,. In bacteria, it remains unclear how rescue pathways …

Abstract Group B Streptococcus (GBS) is the leading cause of neonatal disease worldwide,
and invasive disease in adults is becoming more prevalent. Currently, some countries adopt …