[HTML][HTML] SARS-CoV-2 pathogenesis
MM Lamers, BL Haagmans - Nature reviews microbiology, 2022 - nature.com
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has
caused a devastating pandemic. Although most people infected with SARS-CoV-2 develop …
caused a devastating pandemic. Although most people infected with SARS-CoV-2 develop …
[HTML][HTML] Human genetic and immunological determinants of critical COVID-19 pneumonia
Q Zhang, P Bastard, A Cobat, JL Casanova - Nature, 2022 - nature.com
SARS-CoV-2 infection is benign in most individuals but, in around 10% of cases, it triggers
hypoxaemic COVID-19 pneumonia, which leads to critical illness in around 3% of cases …
hypoxaemic COVID-19 pneumonia, which leads to critical illness in around 3% of cases …
[HTML][HTML] Immune dysregulation and immunopathology induced by SARS-CoV-2 and related coronaviruses—are we our own worst enemy?
Human coronaviruses cause a wide spectrum of disease, ranging from mild common colds
to acute respiratory distress syndrome and death. Three highly pathogenic human …
to acute respiratory distress syndrome and death. Three highly pathogenic human …
[HTML][HTML] Human organoid models to study SARS-CoV-2 infection
Abstract Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) is one of the deadliest pandemics in history. SARS …
syndrome coronavirus 2 (SARS-CoV-2) is one of the deadliest pandemics in history. SARS …
Human distal lung maps and lineage hierarchies reveal a bipotent progenitor
Mapping the spatial distribution and molecular identity of constituent cells is essential for
understanding tissue dynamics in health and disease. We lack a comprehensive map of …
understanding tissue dynamics in health and disease. We lack a comprehensive map of …
[HTML][HTML] Nasal ciliated cells are primary targets for SARS-CoV-2 replication in the early stage of COVID-19
The upper respiratory tract is compromised in the early period of COVID-19, but SARS-CoV-
2 tropism at the cellular level is not fully defined. Unlike recent single-cell RNA-Seq analyses …
2 tropism at the cellular level is not fully defined. Unlike recent single-cell RNA-Seq analyses …
[PDF][PDF] Innate immune and inflammatory responses to SARS-CoV-2: Implications for COVID-19
SA Lowery, A Sariol, S Perlman - Cell host & microbe, 2021 - cell.com
COVID-19 can result in severe disease characterized by significant immunopathology that is
spurred by an exuberant, yet dysregulated, innate immune response with a poor adaptive …
spurred by an exuberant, yet dysregulated, innate immune response with a poor adaptive …
[HTML][HTML] Human alveolar type 2 epithelium transdifferentiates into metaplastic KRT5+ basal cells
JJ Kathiriya, C Wang, M Zhou, A Brumwell… - Nature cell …, 2022 - nature.com
Loss of alveolar type 2 cells (AEC2s) and the ectopic appearance of basal cells in the alveoli
characterize severe lung injuries such as idiopathic pulmonary fibrosis (IPF). Here we …
characterize severe lung injuries such as idiopathic pulmonary fibrosis (IPF). Here we …
[HTML][HTML] Genome-wide bidirectional CRISPR screens identify mucins as host factors modulating SARS-CoV-2 infection
SB Biering, SA Sarnik, E Wang, JR Zengel, SR Leist… - Nature …, 2022 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes a range of
symptoms in infected individuals, from mild respiratory illness to acute respiratory distress …
symptoms in infected individuals, from mild respiratory illness to acute respiratory distress …
An organoid‐derived bronchioalveolar model for SARS‐CoV‐2 infection of human alveolar type II‐like cells
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) causes coronavirus
disease 2019 (COVID‐19), which may result in acute respiratory distress syndrome (ARDS) …
disease 2019 (COVID‐19), which may result in acute respiratory distress syndrome (ARDS) …