Atherosclerotic diseases such as myocardial infarction, ischaemic stroke and peripheral
artery disease continue to be leading causes of death worldwide despite the success of …

Tissue development and homeostasis are controlled by mechanical cues. Perturbation of
the mechanical equilibrium triggers restoration of mechanostasis through changes in cell …

Cardiovascular morphogenesis involves cell behavior and cell identity changes that are
activated by mechanical forces associated with heart function. Recently, advances in in vivo …

The heart is the first functional organ in a developing embryo. Cardiac development
continues throughout developmental stages while the heart goes through a serious of …

Physics-based computational models of the cardiovascular system are increasingly used to
simulate hemodynamics, tissue mechanics, and physiology in evolving healthy and …

Biomechanical forces and endothelial-mesenchymal transition (EndoMT) are known to
mediate valvulogenesis. However, the relative contributions of myocardial contractile and …

Endothelial cells are exposed to fluid shear stress profiles that vary in magnitude, pulsatility,
and directionality due to regional variations in blood vessel structure. Laminar flow at …

Biomechanical forces intimately contribute to cardiac morphogenesis. However, volumetric
imaging to investigate the cardiac mechanics with high temporal and spatial resolution …

Tissue degradation plays a crucial role in vascular diseases such as atherosclerosis and
aneurysms. Computational modeling of vascular hemodynamics incorporating both arterial …

In the adult heart, acute adaptation of electrical and mechanical activity to changes in
mechanical load occurs via feedback processes known as “mechano-electric coupling” and …