Abstract Cancer-on-chip (CoC) models, based on microfluidic chips harboring chambers for
3D tumor-cell culture, enable us to create a controlled tumor microenvironment (TME). CoC …

Microphysiological systems (MPS), also known as miniaturized physiological environments,
have been engineered to create and study functional tissue units capable of replicating …

This study addresses the demand for research models that can support patient-treatment
decisions and clarify the complexities of a tumor microenvironment by developing an …

Tumours are heterogeneous tissues containing diverse populations of cells and an
abundant extracellular matrix (ECM). This tumour microenvironment prompts cancer cells to …

There is a need for better predictive models of the human immune system to evaluate safety
and efficacy of immunomodulatory drugs and biologics for successful product development …

Background With the burgeoning advancements in disease modeling, drug development,
and precision medicine, organ-on-a-chip has risen to the forefront of biomedical research …

Discovered as inflammatory cytokines, MIF and DDT exhibit widespread expression and
have emerged as critical mediators in the response to infection, inflammation, and more …

Vascularized tumor on a chip (VToC) entail emulating intricate microvascular networks like
those observed in tumors through microfluidic devices, which are meticulously designed to …