Asparaginase is an integral component of multiagent chemotherapy regimens for the
treatment of children with acute lymphoblastic leukemia. Positive outcomes are seen in …

Glucocorticoids (prednisone and dexamethasone) play an essential part in the treatment of
acute lymphoblastic leukaemia (ALL), but their optimum doses and bioequivalence have not …

Although infection is the major cause of treatment-related mortality (TRM) in childhood acute
lymphoblastic leukemia, factors associated with infection-related mortality (IRM) are poorly …

Purpose We assessed the toxicity and efficacy of dexamethasone and a novel dosing
method of Escherichia coli L-asparaginase (EC-Asnase) in children and adolescents with …

Children with Down syndrome (DS) have an increased risk of B-cell precursor (BCP) acute
lymphoblastic leukemia (ALL). The prognostic factors and outcome of DS-ALL patients …

Abstract The Children's Cancer Group enrolled 13 298 young people age< 21 years on 1 of
16 protocols between 1983 and 2002. Outcomes were examined in three time periods, 1983 …

Corticosteroids are an essential component of treatment for acute lymphoblastic leukaemia
(ALL). Prednisolone is the most commonly used steroid, particularly in the maintenance …

Background A population-based cohort of children aged 1–18 years with acute
lymphoblastic leukaemia (ALL) was treated with a dexamethasone-based protocol (Dutch …

Background Transient hyperglycemia (TH) is a recognized side effect of the corticosteroids
and asparaginase given during induction chemotherapy for pediatric acute lymphoblastic …

Purpose To evaluate whether dexamethasone (DEXA) yields a better outcome than
prednisolone (PRED) in a prospective, randomized, controlled trial for the treatment of …