Opportunity in nanomedicine to counter the challenges of current drug delivery approaches used for the treatment of malaria: a review
Malaria is a life-threatening parasitic disease transmitted by the infected female Anopheles
mosquito. The development of drug tolerance and challenges related to the drugs' …
mosquito. The development of drug tolerance and challenges related to the drugs' …
Balancing solid-state stability and dissolution performance of lumefantrine amorphous solid dispersions: the role of polymer choice and drug–polymer interactions
Amorphous solid dispersions (ASDs) are of great interest due to their ability to enhance the
delivery of poorly soluble drugs. Recent studies have shown that, in addition to acting as a …
delivery of poorly soluble drugs. Recent studies have shown that, in addition to acting as a …
[HTML][HTML] Physical stability and release properties of lumefantrine amorphous solid dispersion granules prepared by a simple solvent evaporation approach
Amorphous solid dispersions (ASDs) of lumefantrine, which has low aqueous solubility,
have been shown to improve bioavailability relative to crystalline formulations. Herein, the …
have been shown to improve bioavailability relative to crystalline formulations. Herein, the …
Repositioning miconazole nitrate for malaria: Formulation of sustained release nanostructured lipid carriers, structure characterization and in vivo antimalarial …
It has been previously claimed that miconazole (MNZ) has activity against Plasmodium
falciparum in vitro. Therefore, this study aims to evaluate the potential of MNZ as an …
falciparum in vitro. Therefore, this study aims to evaluate the potential of MNZ as an …
Bioavailability of lumefantrine is significantly enhanced with a novel formulation approach, an outcome from a randomized, open-label pharmacokinetic study in …
JP Jain, FJ Leong, L Chen, S Kalluri… - Antimicrobial agents …, 2017 - Am Soc Microbiol
The artemether-lumefantrine combination requires food intake for the optimal absorption of
lumefantrine. In an attempt to enhance the bioavailability of lumefantrine, new solid …
lumefantrine. In an attempt to enhance the bioavailability of lumefantrine, new solid …
[HTML][HTML] Magnetic-guided targeted delivery of zerumbone/SPION co-loaded in nanostructured lipid carrier into breast cancer cells
Zerumbone (ZER), a potential anticancer agent for breast cancer treatment, has limited
clinical applications due to its poor water solubility and targeting ability. The poor water …
clinical applications due to its poor water solubility and targeting ability. The poor water …
Solid lipid nanoparticles encapsulating a fluorescent marker (coumarin 6) and antimalarials–artemether and lumefantrine: evaluation of cellular uptake and …
Artemisinins, the mainstay in the treatment of malaria today, are used in combination with
other antimalarials to forestall resistance, as artemisinin-combination therapies. In line with …
other antimalarials to forestall resistance, as artemisinin-combination therapies. In line with …
Intranasal artesunate-loaded nanostructured lipid carriers: A convenient alternative to parenteral formulations for the treatment of severe and cerebral malaria
CP Agbo, TC Ugwuanyi, WI Ugwuoke… - Journal of Controlled …, 2021 - Elsevier
Early treatment with parenteral antimalarials is key in preventing deaths and complications
associated with severe and cerebral malaria. This can be challenging in 'hard-to …
associated with severe and cerebral malaria. This can be challenging in 'hard-to …
22 factorial design-based biocompatible microneedle arrays containing artemether co-loaded with lumefantrine nanoparticles for transepidermal delivery
S Pawar, P Shende - Biomedical Microdevices, 2020 - Springer
The present study was intended to enhance the permeation of artemether and lumefantrine
by encapsulating in dissolvable microneedle arrays for extended action. Lumefantrine …
by encapsulating in dissolvable microneedle arrays for extended action. Lumefantrine …
[HTML][HTML] Optimizing derivatization conditions using an experimental design and simultaneous estimation of artemether and lumefantrine by ratio first order derivative …
J Christian, P Shah, M Patel, K Patel… - Journal of Taibah university …, 2017 - Elsevier
Artemether–lumefantrine is the most widely used artemisinin-based combination therapy for
malaria. The present work aims to develop and validate a simple, accurate, precise and …
malaria. The present work aims to develop and validate a simple, accurate, precise and …