Opioids induce respiratory depression via activation of μ-opioid receptors at specific sites in
the central nervous system including the pre-Bötzinger complex, a respiratory rhythm …

Currently, no single medication has been approved for the management of coronavirus
disease-2019 (COVID-19) caused by the new severe acute respiratory syndrome …

Genetic polymorphisms result in absent enzyme activity of CYP2D6 (poor metabolizers, PM)
in about 10% of the Caucasian population. This study investigates whether the PM genotype …

We studied whether tramadol administered at the time of wound closure can prevent
postanaesthetic shivering. One hundred and fifty patients scheduled for general anaesthesia …

The experiments were done on frog sciatic nerves, using a sucrose-gap recording
technique. The aim of our study was to investigate and to compare the tonic and phasic …

Background. The aim of this study was to evaluate the efficacy of tramadol as an adjuvant to
the local anaesthetic solution in patients undergoing shoulder arthroscopy for rotator cuff …

Background Thyroidectomy is a common procedure that causes mild trauma. Nevertheless,
postoperative pain remains a major challenge in patient care. Multimodal analgesia …

Background and purpose: Although tramadol is known to exhibit a local anaesthetic effect,
how tramadol exerts this effect is not understood fully. Experimental approach: The effects of …

JUSTIFICATIVA E OBJETIVOS: As citocinas pró-inflamatórias têm função importante na
fisiopatologia das síndromes dolorosas neuropáticas. O objetivo desse estudo foi avaliar os …

The effects of tramadol on repetitively elicited action potentials were studied in rat sciatic
nerve, using the sucrose gap method. Tramadol's local anesthetic-like effects were …