Both neutrophil extracellular traps (NETs) and von Willebrand factor (VWF) are essential for
thrombosis and inflammation. During these processes, a complex series of events, including …

Together with seven ADAMTS-like proteins, the 19 mammalian ADAMTS proteases
constitute a superfamily. ADAMTS proteases are secreted zinc metalloproteases whose …

Abstract von Willebrand factor (VWF) is a large adhesive glycoprotein with established
functions in hemostasis. It serves as a carrier for factor VIII and acts as a vascular damage …

The a disintegrin-like and metalloproteinase with thrombospondin motif (ADAMTS) family
comprises 19 proteases that regulate the structure and function of extracellular proteins in …

Thrombotic thrombocytopenic purpura (TTP) is a disorder with characteristic von Willebrand
factor (VWF)-rich microthrombi affecting the arterioles and capillaries of multiple organs. The …

Metalloproteinases are among the most abundant toxins in many Viperidae venoms. Snake
venom metalloproteinases (SVMPs) are the primary factors responsible for hemorrhage and …

A disintegrin and metalloproteinase (ADAM) family proteins constitute a major class of
membrane-anchored multidomain proteinases that are responsible for the shedding of cell …

A disintegrin and metalloprotease with thrombospondin motifs 13 (ADAMTS13) is a
metalloprotease that regulates von Willebrand factor (VWF) function. ADAMTS13-mediated …

Congenital thrombotic thrombocytopenic purpura (TTP)(also known as Upshaw‐Schulman
syndrome, USS) is a rare, life‐threatening disease characterized by thrombocytopenia and …

Summary ADAMTS‐13, a plasma reprolysin‐like metalloprotease, cleaves von W illebrand
factor (VWF). Severe deficiency of plasma ADAMTS‐13 activity results in thrombotic …