Treatment strategies for patients with diffuse large B-cell lymphoma

S Poletto, M Novo, L Paruzzo, PMM Frascione… - Cancer treatment …, 2022 - Elsevier
Diffuse large B-cell lymphoma (DLBCL) is nowadays a curable disease with the frontline
treatment R-CHOP, but 30–40% of patients are still unresponsive or relapse thereafter. In …

Diffuse large B-cell lymphoma: optimizing outcome in the context of clinical and biologic heterogeneity

LH Sehn, RD Gascoyne - Blood, The Journal of the American …, 2015 - ashpublications.org
Although the majority of patients with diffuse large B-cell lymphoma (DLBCL) can be cured
with standard rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R …

ROBUST: a phase III study of lenalidomide plus R-CHOP versus placebo plus R-CHOP in previously untreated patients with ABC-type diffuse large B-cell lymphoma

GS Nowakowski, A Chiappella… - Journal of Clinical …, 2021 - ascopubs.org
PURPOSE Patients with the activated B-cell-like (ABC) subtype of diffuse large B-cell
lymphoma (DLBCL) historically showed inferior survival with standard rituximab plus …

Obinutuzumab or rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone in previously untreated diffuse large B-cell lymphoma

U Vitolo, M Trněný, D Belada, JM Burke… - Journal of clinical …, 2017 - ascopubs.org
Purpose Rituximab (R) plus CHOP (cyclophosphamide, doxorubicin, vincristine,
prednisone) chemotherapy is the standard of care in previously untreated diffuse large B …

Diffuse large B-cell lymphoma (DLBCL): ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

H Tilly, MG Da Silva, U Vitolo, A Jack… - Annals of …, 2015 - annalsofoncology.org
Diffuse large B-cell lymphoma (DLBCL) constitutes 30%–58% of non-Hodgkin's lymphoma
series. The crude incidence in Europe is 3.8/100 000/year [1]. The incidence increases with …

Genetic alterations and their clinical implications in DLBCL

Y Miao, LJ Medeiros, Y Li, J Li, KH Young - Nature reviews Clinical …, 2019 - nature.com
Diffuse large B cell lymphoma (DLBCL) is a highly heterogeneous lymphoid neoplasm with
variations in gene expression profiles and genetic alterations, which lead to substantial …

Mechanisms of action of lenalidomide in B-cell non-Hodgkin lymphoma

JG Gribben, N Fowler, F Morschhauser - Journal of Clinical Oncology, 2015 - ascopubs.org
Lenalidomide is an orally active immunomodulatory drug that has direct antineoplastic
activity and indirect effects mediated through multiple types of immune cells found in the …

Lenalidomide maintenance compared with placebo in responding elderly patients with diffuse large B-cell lymphoma treated with first-line rituximab plus …

C Thieblemont, H Tilly, M Gomes da Silva… - Journal of Clinical …, 2017 - ascopubs.org
Purpose The standard treatment of patients with diffuse large B-cell lymphoma (DLBCL) is
rituximab in combination with cyclophosphamide, doxorubicin, vincristine, and prednisone …

Impact of dual expression of MYC and BCL2 by immunohistochemistry on the risk of CNS relapse in DLBCL

KJ Savage, GW Slack, A Mottok… - Blood, The Journal …, 2016 - ashpublications.org
Dual expression of MYC and BCL2 by immunohistochemistry (IHC) is associated with poor
outcome in diffuse large B-cell lymphoma (DLBCL). Dual translocation of MYC and BCL2, so …

Novel drug targets for personalized precision medicine in relapsed/refractory diffuse large B-cell lymphoma: a comprehensive review

R Camicia, HC Winkler, PO Hassa - Molecular cancer, 2015 - Springer
Diffuse large B-cell lymphoma (DLBCL) is a clinically heterogeneous lymphoid malignancy
and the most common subtype of non-Hodgkin's lymphoma in adults, with one of the highest …